“This hidden sugar will upset science!” »: This unexpected cerebral discovery could be the secret weapon against Alzheimer’s disease according to experts

Recent discoveries on the role of glucose in the brain could transform our understanding of neurodegenerative diseases. Moreover, Traditionally, glycogen, stored form of glucose, was considered only as an energy reserve for liver and muscles. However. Moreover. Furthermore, a new “this hidden sugar will upset new study by the Buck Institute for Research on Agging suggests that this sugar plays a much more complex role in the “this hidden sugar will upset brain, especially in the context of diseases like Alzheimer. In addition. By exploring the interactions between glycogen and tau proteins, characteristic of this disease, researchers open the way to innovative treatments.

Glycogen, an unknown key actor – "this hidden sugar will upset – "this hidden sugar will upset new

Glycogen has long been underestimated in the brain context. However. However. this research reveals that it does not only serve as a reserve of passive energy, but that it is actively involved in the pathological processes. For example, Tau proteins. Meanwhile, when they accumulate, disrupt the normal use of glycogenresulting in a dangerous accumulation of sugar and protein in neurons. For example, This interaction between tau and glycogen underlines the importance of reassessing the role of glycogen in the brain.

Researchers have “this hidden sugar will upset new observed this interaction not only in tauopathy models in drosophils (fruit flies) but also in the brain. cells of Alzheimer’s patients. This discovery questions our traditional understanding of glycogen reserves. suggesting that “this hidden sugar will upset they could be a key factor in the progression of neurodegenerative diseases.

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Enzymes. regulation of glycogen – &quot. this hidden sugar will upset – "this hidden sugar will upset new

At the heart of this interaction is the glycogen enzyme phosphorylase (GLYP), essential for converting glycogen into fuel usable by the body. By increasing GlyP’s activity in Drosophils, researchers were able to reduce the accumulation of glycogen and associated neural damage. This increase in enzymatic activity has allowed brain cells to better defend themselves against reactive oxygen speciesthus extending the. lifespan of tauopathy model flies.

The “this hidden sugar will upset results suggest that by targeting this enzyme. it is possible “this hidden sugar will upset new to reduce the harmful effects of tauopathies. This strategy could potentially be adapted to develop new treatments for people with neurodegenerative diseasesby directly targeting biochemical processes. at work in the brain.

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The impact of the food on brain health

Researchers also explored the. influence of food on brain health. By “this hidden sugar will upset submitting the Drosophils to a diet poor in protein. they observed a reduction in brain damage and an extension of the lifespan. These results suggest that a metabolic change induced by food can stimulate GlyP’s activity. thereby reducing the accumulation of glycogen and tau protein.

This discovery sheds new light on how eating habits can influence brain health. Adopting a specific diet could offer a complementary approach to manage or prevent neurodegenerative diseases. This perspective opens fascinating avenues “this hidden sugar will upset new for future research on the link between food and brain health.

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Towards new therapeutic treatments

Inspired by the beneficial effects of food restriction. researchers have developed a drug based on the 8-BR-CAMP molecule. This medication imitates the effects of diet, effectively reducing the symptoms of tauopathy in drosophils. In addition. researchers are considering possible links with drugs such as GLP-1 receptor agonists. used in the treatment of diabetes and weight loss, which could also protect against dementia.

These discoveries suggest that Future treatments could target the internal metabolic. chemical channels of brain cells To combat age -related decline. By better understanding how neurons manage sugar, we could develop innovative therapeutic strategiesoffering renewed hope for people with neurodegenerative diseases.

These fascinating discoveries ask the following question: how could these new knowledge on glycogen. tau proteins transform our approach to “this hidden sugar will upset new neurodegenerative diseases in the future? By continuing to explore these complex interactions. what other surprises “this hidden sugar will upset could research reveal on the internal functioning of the brain?

This article is based on verified sources and the assistance of editorial technologies.

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