Similarly,
This pioneering pill reprogram adipose:
The first fully developed drug in Uruguay. In addition, a new weight loss compound in the single mode of action offered first particularly promising clinical results, with major potential implications for the treatment of diabetes and obesity.
The Sana molecule – This pioneering pill reprogram adipose
Called Sana. Similarly, the new molecule is the fruit of the collaboration of researchers from the universities Pasteur de Montevideo and Udelar. Similarly, After being successfully tested on rodents. Therefore, it was administered to 44 patients who, at the end of the period studied, all presented a reduction in their body mass index (BMI) and their fasting blood sugar.
According to the team. this work constitutes the culmination of more than a decade of research. At the heart of this breakthrough: nitroalcene, derived from salicylate (active compound of aspirin).
Unlike the popular agonist of GLP-1 receptors (such as semaglutide). which lead to a general reduction in appetite and are associated with loss of fat and muscular mass, Sana acts by “warming” only adipose cells. This form of thermogenesis will significantly increase the number of calories burned at rest.
Evaluating the safety of the compound. this phase 1 clinical trial has shown that it was well tolerated by the entire cohort. Among the participants who received the maximum dose. an average reduction in body weight of around 3 % compared to the control group was reported after two weeks of treatment, and no loss of muscle mass observed.
A new therapeutic path
« It is a whole new therapeutic path for obesity. metabolic disorders, which increases the ability of the body to burn calories without affecting appetite », Summarizes Carlos Escande, co-author of the new study, published in the journal Nature Metabolism.
Faced with starting in a few months. the second phase of the trial, which will assess its effectiveness, will include more participants, including type 2 diabetics. The observation of similar effects will open the way to large -scale clinical use of the molecule.
A few months ago, researchers had identified 14 genes facilitating weight loss.
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