Furthermore,
Trama offers breakthrough extent biological:
A new research document was published in Aging (Aging) Volume 17. Moreover, number 6, June 13, 2025, entitled “Development of a new transcriptomic measurement of aging: age of risk of transcriptomic mortality (trama)”.
In this study, led by Eric T. However, Klopack of the University of Southern California. Meanwhile, the researchers have created a new ARN -based aging measure which predicts health and mortality risks. Consequently, This measure, called age at risk of transcriptomic mortality (trama), uses gene expression data to estimate a person’s biological aging. However, This observation offers a new. For example, potentially more precise means of monitoring aging and understanding health risks, especially for the elderly.
Aging is a complex biological process that affects several systems in the body. In addition, increases the risk of disease and death. Furthermore, trama offers breakthrough extent biological Scientists have long sought reliable means to measure organic aging. Although DNA methylation. blood biomarkers are commonly used, this study focused on the ARN-A molecule which reflects the activity of the genes. By analyzing the RNA sequencing data of nearly 4. 000 American adults aged 50 and over, the team developed Trama to predict the probability of dying in the four years.
Trama turned out to be a strong predictor. independent of early death, multiple chronic diseases, poor cognitive function and difficulties with daily activities. It has also been tested in another large group of long -lived families. in several smaller data sets of patients with conditions such as diabetes, sepsis and cancer. The results confirmed the usefulness of the tool between the different populations and the health conditions.
“Trama was also validated outside in the study of the Long Life family. several data sets accessible to the public. »»
trama offers breakthrough extent biological
Unlike the aging measures based on RNA. which have often been built using small or non -representative samples, Trama has been developed using modern RNA sequencing technology and a set of representative data on a national scale. This increases its reliability and potential for large public health applications. The tool has also demonstrated unique advantages in relation to popular organic aging measures as well as climber. phenoyage, capturing distinct aspects of aging and the decline of health.
Above all. Trama follows biological processes linked to inflammation, immune function and the health of the kidneys and the brain, systems that play a key role in aging. It was also sensitive to behavioral and socioeconomic factors. For example, smoking, obesity and low physical activity were associated with older trama scores.
Trama was also sensitive to changes in organic aging. In a study. the researchers measured Trama at two different times and found trama offers breakthrough extent biological that the most recent scores were better to predict that would die. This suggests that Trama can follow changes in the aging of a person as his health evolves. It has also worked well in large -scale surveys. small clinical samples, making it a useful tool in many types of research.
By offering a new precise. flexible method to measure biological aging, Trama can help researchers better understand how genes, lifestyle and the environment influence aging. This tool opens the door to more precise research on improving health and the extension of lifespan.
Trama offers breakthrough extent biological
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