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Aging is a complex process that does not always take place gradually. Recent research has revealed that human aging could have two significant accelerations during life. These discoveries, from a study by the geneticist Michael Snyder and his colleagues from the University of Stanford, highlight significant molecular changes occurring at specific ages. These critical phases, identified on average at 44 and 60, could explain why certain diseases become more frequent at these ages. The exploration of these transformations opens the way to a better understanding and potentially to new approaches to mitigate the risks of diseases associated with age.
Critical ages of human aging
According to the study, the ages of 44 and 60 years mark periods of spectacular changes in the human body. These transition moments are characterized by modifications in the abundance of various molecules. At 44, changes particularly concern the metabolism of lipids, caffeine and alcoholas well as dysfunctions linked to cardiovascular disease, skin and muscles. The following peak, at 60, sees transformations in the metabolism of carbohydrates and caffeine, as well as alterations in renal function and immune regulation. These findings, which concern a majority of the molecules studied, underline the importance of these ages in the aging process.
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Biomarkers of aging
To understand these accelerations, the researchers followed a group of 108 adults, regularly collecting organic samples over several years. This intensive monitoring made it possible to collect more than 246 billion data points, revealing reasons of change. Biomolecules studied included RNA, proteins, lipids and various microbiomassuch as those of the skin and the intestine. Analysis has shown that around 81 % of molecules underwent changes during the identified periods. The results of this research offer a fascinating overview of the internal mechanisms of aging, suggesting that these biomarkers could be key indicators for the early diagnosis of age -related diseases.
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Impact of molecular health changes
The results of the study have significant implications for human health. Researchers have observed that the risk of certain diseases, such as Alzheimer’s disease and cardiovascular disease, increases considerably after a certain age rather than gradually. Understanding molecular changes at critical ages could lead to more effective prevention strategies. Although menopause or perimenopause can play a role in the changes observed in women around 44 years old, researchers have noted that more significant factors are probably at stake, also affecting men. This underlines the importance of continuing research to identify these factors and develop targeted interventions.
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Perspectives for future research
Although the study has provided valuable information, it has certain limitations due to the relatively small size of the sample and the limited age beach of the participants. The researchers highlight the need for more in -depth studies, involving a wider range of subjects to validate their conclusions. Exploring these molecular changes to a more granular level could reveal crucial details on how the human body adapts over time. This could also pave the way for new therapeutic approaches to slow down or even reverse certain aspects of aging.
This study on the acceleration of human aging offers a new fascinating perspective on our understanding of age and its effects on health. By identifying critical periods of molecular change, it raises important questions about how we could better manage aging and its consequences. How could these discoveries influence our approach to preventive health care in the future?
The author relied on artificial intelligence to enrich this article.
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