Furthermore,
Vaccine offers hope against pancreatic:
To UNITED STATESresearchers have tested a therapeutic vaccine specifically targeting the genes of the gene KRAS In patients with pancreatic and colonized cancer. Nevertheless, The first results suggest an extended immune response and prolonged survival for several participants.
Innovative technology to mobilize the immune system – Vaccine offers hope against pancreatic
The vaccine Eli-002 2pdescribed in the study published in Nature Medicineuses Small portions of protein corresponding to the KRAS mutations present in cancer cells. Similarly, associated with an adjuvant. These components are chemically adapted to bind to albuminwhich allows them to be used effectively to the lymph nodes. Consequently, where immune cells develop and prepare to act.
This method allowed Activate the two main types of T. CD4+ and CD8+ lymphocytes, capable of intervening directly or indirectly on cancer cells. Pour Olivier LantzDirector of the clinical immunology laboratory at the Institut Curie vaccine offers hope against pancreatic in Paris. the technique bypass one of the major limits of current vaccines: The ineffective routing to the lymph nodes.
Significant. sustainable immune responses
The test was carried out on 25 participants, including 20 suffering from pancreatic cancer and 5 with colorectal cancer. Among them, 68% developed a significant response from T lymphocytes to KRAS protein. Moreover, 67% presented a spread of this immune reaction to other tumor mutations which were not targeted at the start.
The Dr Zev Wainbergoncologist at Jonsson Cancer Center of the University of California in Los Angelesnote that patients with the most important immune responses have benefited from a 15 -month recurrence survival. a Global survival of 29 monthsdurations superior to the standard usually observed. These results were published in Nature Medicine.
Perspectives for the treatment of Kras cancer
Gene mutations KRAS are frequent in certain digestive cancers. remain difficult to target with vaccine offers hope against pancreatic conventional treatments. Therapeutic vaccines aim to Generate a specific immune response. offering the possibility of lengthening the survival of patients while minimizing undesirable effects.
The originality of this approach lies in the possibility of triggering protection against several mutations without having to create. a fully personalized vaccine for each patient. Smart tests and prolonged follow -ups will fully assess the efficiency and safety of this strategy. American researchers continue to develop the vaccine to test its potential on other types of cancers with similar mutations.
Further reading: Faced with a contagious person, the brain activates a preventive immune response | The doctor’s daily life – “It is a miracle”: seriously injured during a Camarguan race, the doorman of the mauguio arenas is out of danger – Bacteremia with golden staphylococcus: dalbavancin with only two effective injections… but not superior | The doctor’s daily life | Specialties – Paranoia and hallucinations: a man poisoning himself by following the medical advice of Chatgpt – A new study reveals a link between vaccines and infertility? (No, that’s wrong).
