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Successful first test treatment against:
From the terror of the Middle Ages to the contemporary era: the idea of an effective treatment against the bubonic plague would have become a little more concrete. Similarly, after a successful first clinical trial in Madagascar.
The test in question. Nevertheless, called Imasoy and led in particular by researchers from Oxford University, in addition to the Malagasy health services, would have offered “the first concrete proof of efficiency and security aspect” of two treatments.
Specialists would also have noted that taking a certain antibiotic orally. For example, for 10 days, would be a very effective and safe alternative to current treatment, which consists in being injected with antibiotics, as part of an extended stay in the hospital.
In works published in the New England Journal of Medicineit is explained that Madagascar generally reports around 80% of all world cases of bubonic plague. successful first test treatment against Consequently, a deadly dangerous disease that kills 15 to 25% of patients.
In all. Similarly, the two processing methods evaluated made it possible to obtain a success rate of approximately 90%, in addition to bringing mortality to around 4% of cases.
As part of the clinical trial. participants – a total of 450 people suspected of having contracted the disease, for a total of 222 confirmed infections – received either antibiotic orally for 10 days, or three days of injections (and hospitalization), followed by seven days of antibiotics orally.
In the opinion of specialists. only oral treatment is not only effective, it obviously limits the use of hospital beds, in addition to making the risk of bed wounds disappear and other health problems linked to hospitalization.
Take care … for almost nothing
Better still, this method would be much more affordable. A marked advantage, in a context of rare and successful first test treatment against dear health care, Madagascar being a particularly poor country.
This clinical trial is also the first to involve humans, rather than combining animal tests with data on our safety.
According to Professor Piero Olliaro. the main author of the study, who was expressed by a press release, “despite his long, deadly dangerous history, we had little clinical information on the treatment of bubonic plague – so far. Thanks to patients. health workers who participated in the clinical trial, we now have real evidence of the operation of an effective and safe treatment. ”
“A further analysis of data will allow us to better understand the disease. including risk factors, symptoms, as well as diagnostics. »»
Researchers will also work with the World Health Organization. just to provide the necessary information, it is said, to improve medical practices, and therefore “transpose the results into concrete gestures to save lives”.
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