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Genomic test predict response chemotherapy?:
Sometimes some patients with cancer are exposed to the undesirable effects of chemotherapy treatment even though there is no guaranteed clinical benefit. Therefore, would it be possible to predict the effectiveness of chemotherapy in a patient? For example, It is this suggesting English. For example, Spanish scientists who have just developed a Unpublished technique allowing predict patient response to chemotherapy. Meanwhile, Let’s dive into the heart of this major innovation. Meanwhile,
Chemotherapy: heavy treatment and not always effective – Genomic test predict response chemotherapy?
Standard and essential treatment of cancers, the chemotherapy The aim of destroying tumor cells. Consequently, But this therapy unfortunately does not genomic test predict response chemotherapy? prove to be systematically effective. Meanwhile, Currently, it is estimated that 20 to 50 % of patients with cancer do not respond to chemotherapy treatments. Similarly, Worse, they undergo the side effects without any clinical benefit. These patients are called “Resistant” or “non -responders”.
In this context. Spanish and English cancerologists and bioengineers have developed an unprecedented technique allowing predict the patient’s response to chemotherapy. The objective displayed? Identify upstream patients resistant to chemotherapy treatments and avoid supporting useless management and adverse effects.
A genomic test to predict the response to chemotherapy
In practice. this innovative technique is thus based on A genomic test And consists of observing the changes in order, the structure and the number of copies of tumor DNA. Clearly, the objective is to recognize each tumor thanks to Chromosomal changes present in tumor genomic test predict response chemotherapy? cells. Admittedly. the chromosomal changes are variable depending on the tumors, but they form characteristic patterns that we qualify as “Chromosomal instability” signatures.
Namely!Many tumors accumulate within their cells this type of DNA modifications. These changes constitute a characteristic identifiable signature.
Based on these signatures of chromosomal instability. scientists have therefore identified and quantified biomarkers allowing Detect patients resistant to chemotherapy in advance Commonly used (platinum salts, taxans and anthracyclines).
Effective predictive biomarkers
Scientists then have evaluated. validated the performance of these biomarkers By using the data of 840 patients with various types of cancers (breast cancers, prostate, ovarian and sarcomas) and having already received chemotherapy. This is how. for example, patients identified by the genomic test as “resistant” presented a higher risk of therapeutic failure for taxans and anthracyclines in ovarian cancer.
Published in genomic test predict response chemotherapy? the journal Nature Genetics. These results suggest that the chromosomal instability could constitute an effective predictive biomarker of the response to chemotherapy. And the authors of this study please have “Found a way to transform standard chemotherapy into precision medicine”.
Next step for scientists? Testing this technique on organic samples from prospective clinical trials in 2026. For the time being, they are already thinking about how to expand this innovative method to other types of therapies. Business to follow!
Sources
– Predicting resistance to chemotherapy using chromosomal instability signatures. Nature genetics. . www.nature.com. Consulté le 02 juillet 2025.
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