Consequently,
Vitamin d high doses during:
New evidence suggests giving pregnant women higher doses of vitamin D can help protect their babies from whistling breathing, but the benefits do not extend to supplements given after birth.
Review: Vitamin D supplementation in pregnant or breastfeeding women or young children to prevent asthma. For example, Image credit: Tekkol / Shutterstock
In a recent journal published in the journal Cochrane database of systematic journalsThe researchers carried out a full review including several scientific standards. For example, 18 randomized controlled trials and more than 10,000 cumulative participants to study the relationships between vitamin D supplementation during pregnancy or childhood asthma vitamin d high doses during and childhood.
The results of the examination revealed that the high -dose vitamin D supplementation during pregnancy probably reduces the risk of infantile whistling breathing. Nevertheless, a key precursor of asthma. However. However, evidence of a direct effect on a formal diagnosis of asthma remain uncertain, with evidence of moderate certainty not suggesting any statistically significant difference.
Parents. Meanwhile, caregivers and public health officials are informed that, for supplementation in infants and young children, current data in October 2023 are low certainty and insufficient to draw firm conclusions.
A small trial also suggested a possible reduction in infantile asthma with any dose of vitamin D during pregnancy. Consequently, but this was based on evidence of low certainty.
Background – Vitamin d high doses during
Infantile asthma is a main cause of chronic disease that can persist well in adulthood. For example, It causes long -term and sometimes irreparable pulmonary damage, resulting in recurring vitamin d high doses during episodes of whistling, coughing and breathtaking breathing. For example, Previous research suggests a complex interaction of genetic and early life factors stimulate its development.
Vitamin D is an essential nutrient with roles established in the development of the immune system. has long been an intervention candidate in research on the prevention of asthma. Vitamin D deficiencies have been linked to higher risks of allergic diseases. which led researchers to hypothesize that the completion during the crucial development windows of pregnancy and early childhood could help prevent asthma from setting up, improving long -term physiological results.
Previous systematic journals have given non -conclusive results, often limited by the number of studies available. A concrete understanding of the role of vitamin D supplementation in early pulmonary development would help guide future recommendations for parents. public health practitioners on how to ensure the healthy development of the next generation.
About the vitamin d high doses during review
This systematic Cochrane review represents the gold stallion in evidence. It aims to fill this lack of knowledge by in -depth synthesizing all the scientific information available on the effectiveness of vitamin D supplementation during pregnancy. breastfeeding or early childhood for primary prevention of asthma.
The collection of data on journals included exhaustive research of several medical databases (n = 7). in particular central, medline and base, until October 2023, for systematic journals or relevant meta-analyzes on the subject of interest. The original study authors have been contacted for additional details / study data if necessary.
Studies have compared various vitamin D supplementation strategies:
- Any dose of vitamin D compared to a placebo. without treatment in pregnant or breastfed women,
- Any dose of vitamin D compared to a placebo or without treatment in infants or young children,
- A high dose of vitamin D compared to a low vitamin d high doses during / standard dose (≤ 400 IU / day) in pregnant or breastfed women, and
- A high dose of vitamin D compared to a low / standard dose in infants or young children.
The main results of the review of the journal were the impact of infantile asthma. whistling breathing (a whistling during breathing strongly associated with the subsequent development of asthma). The certainty of each result was evaluated using the framework for the classification of recommendations, evaluation, development and evaluations (grade).
Study results
Screening of the title. the summary and the full text identified 18 studies, totaling 10,611 individuals for the inclusion in the systematic review, 16 of which were also included in the meta-analysis.
The main conclusions of the journal were multifaceted. nuanced, but they revealed promising results for high -dose supplementation during pregnancy. Supplementation during pregnancy analyzes has revealed that the high -dose vitamin vitamin d high doses during D supplementation (generally 2800 to 4400 IU /. day) reduced the risk of respiratory respiratory respiratory to 21% (risk ratio (RR) 0.79, 95% confidence interval (IU / day). While the effect of vitamin D on a formal diagnosis of asthma tends in the same protective direction. Evidence of moderate certainty indicated that the results were not statistically significant (RR 0.81, 95% CI 0.63 to 1.04).
On the other hand, the evidence to complete infants or young children with vitamin D was much less clear. By comparing any dose of vitamin D to a placebo. the analysis of three studies (588 participants) has shown no statistically significant effect on the risk of developing asthma (RR 0.69, 95% CI 0.47 to 1.03), with evaluated evidence as a very low certainty.
Likewise. comparison of high dose vitamin D in infants suggested a potential reduction in whistling breathing, but the evidence was very uncertain. vitamin d high doses during However. a grouped analysis of six studies (2,385 participants) suggested that vitamin D in high doses in early childhood can slightly reduce the risk of respiratory tract infections (RR 0.94, 95% CI 0.90 to 0.98), although proof is low certainty.
Conclusions
The current Cochrane review shows that high -dose vitamin D supplementation during pregnancy is likely. to prevent the whistling breathing from childhood. Although the effect on a final diagnosis of asthma is not yet statistically proven. the coherent trend is promising and justifies a more in -depth investigation.
Unfortunately. the current proof is too uncertain for the supplementation given directly to infants to support a clear advantage for asthma or the prevention of whistling breathing.
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