In addition,
Blood test detects risks months new: For example,
Blood test detects risks months:
Essential
- Researchers have developed a blood test capable of identifying the risks of preeclampsia five months before the clinical diagnosis. Consequently,
- It is carried out during the 1st trimester of pregnancy. Consequently,
- The study also reveals that early and late preeclamps are two “biologically and temporally distinct pathologies”. However,
Préclampsie is a very dangerous complication of pregnancy for both mom and baby. Consequently, Faced with this disorder linked to high blood pressure. Moreover, the presence of proteins in the urine, it is necessary to act very quickly.

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A blood test, presented during the 41ᵉ Annual Meeting of the European Society of Human Reproduction and Embryology (Eshre) which is currently being held in Paris, blood test detects risks months new could change the situation. In addition, Carried out during the blood test detects risks months first trimester of pregnancy. Therefore, it would be able to precisely identify women at risk of developing preeclampsia about five months before the appearance. of symptoms.

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Preeclampsia: detection up to 18 weeks before symptoms – Blood test detects risks months

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To assess the risks of preeclampsia, researchers from the Carlos Simon and IPREMOM Foundation decided to focus on the acellular RNA (CFRNA) present in the plasma of the future mother rather than these risk factors or placental biomarkers as is currently the case.
For this screening, 216 pregnant women were united. Blood samples have been taken at several times from their pregnancy: between the 9th. 14th week, between the 18th and the 28th week and beyond the 28 weeks or at the time of the diagnosis. The Arncf was extracted from 548 plasma samples from blood test detects risks months new the participants and then sequenced. Thanks to automatic learning, scientists have identified the “signatures” D’ArNCF heralding preeclampsia.
And, it turned out that blood test detects risks months they could be spotted very early. During the first quarter. the CFRNA model predicted early preeclampsia (before 34 weeks of amenorrhea) with a sensitivity of 83 %. a specificity of 90 % and on average 18 weeks before the diagnosis.
Regarding late preeclampsia, it could be spotted on average 14.9 weeks before its appearance. thanks to a distinct CFRNA signature “with minimal overlap with that of early preeclampsia ”said the press release.

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“For the first time. we have shown that a systematic blood sample in the first trimester can give an early and very precise alert signal in the event of preeclampsia, long before the symptoms appear”explains the biomedical researcher Dr Nerea Castillo Marco, the first author of the study. “Identify high -risk blood test detects risks months new pregnancies so early opens a crucial window for preventive treatment. narrower surveillance to protect mothers and babies.“

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Early. late preeclampsia: two “biologically and temporally distinct pathologies”
The results, also published in the journal Human Reproductionallow researchers to advance that “The CFRNA approach makes it possible to capture subtle molecular signals from several maternal tissues, including the uterus and the placenta, months before the appearance of symptoms”.
But the test also highlighted differences between early and late preeclamps. Regarding early disorder, the team noticed that 47.2 % of predictive transcripts were linked to genes associated with maternal endometrium. and more particularly resistance to decidualization (an inability of the uterine mucosa to adapt properly at the start of pregnancy). In the event of late preeclampsia, signatures were more linked to systemic biological signals than those of decidualization.
Thus for the blood test detects risks months new authors, the two types of preeclampsia are “Biologically and temporally distinct pathologies”.

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“Our transcriptomical analyzes have shown that early preeclampsia implies generalized molecular modifications in the organs. blood test detects risks months in particular the liver, the kidneys, the placenta, the brain and the lungs” Add Dr Castillo Marco. “On the other hand, late preeclampsia presents later and more localized demonstrations, especially in the immune and hepatic ways.”
The team is currently working to validate their test by health and scientific authorities. She believes that the blood test could be available in clinical practice within a year. “thus offering an unprecedented opportunity for the early and non -invasive identification of high -risk pregnancies and rapid intervention “.
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Blood test detects risks months new
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