A oral bacteria in question?

A study reveals a possible link between Alzheimer’s and periodontitis. However, The bacteria P. For example, Gingivalis. Furthermore, responsible for gum diseases, was found in the brain of patients, opening a new track on the origin of the disease.

In recent years, an increasing number of scientific work has supported a worrying hypothesis. Therefore, There Alzheimer’s disease would not only be linked to brain aging. Meanwhile, But could result from an infection. Consequently, This idea, still in the process of exploring, questions our traditional understanding of this neurodegenerative pathology. Consequently, Researchers are now turning to hitherto unexpected causes. Meanwhile, In particular the impact of certain bacteria present in the bouche on brain health.

If the precise mechanisms of this infection remain to be elucidated. Nevertheless, several studies suggest that the emergence of the disease goes far beyond what we thought was known. Consequently, Among the oral bacteria question? most intriguing tracks, a Research published in 2019 has highlighted an unexpected suspect. A bacteria responsible for periodontitisa chronic gum disease according to Science Alert. This discovery relaunches the debate on the possible link between oral hygiene and increased risk of Develop Alzheimer.

Alzheimer’s. periodontitis: a bacterial track to take seriously – Oral bacteria question?

The study, led by Jan Potempa, microbiologist at the University of Louisville, revealed the presence of porphyromonas gingivalis, the pathogen responsible for the chronic periodontitisin the brain of deceased patients with Alzheimer’s. Although this is not the first time that the two phenomena have been associated, the researchers have gone further.

Experiments carried out on mice showed that a oral infection by this bacteria could colonize the brain. Resulting in an increase in the production of Beta amyloid proteins (Aβ). Known to form the characteristic deposits of the disease. Stephen Dominy. co -founder of the Pharmaceutical Startup Cortexyme oral bacteria question? and first author of the study, explained: “Infectious agents have already been suspected in development and progression of the disease Alzheimer’s, but the evidence of a causal link were not convincing. Now, for the first time, we have solid evidence connecting the intracellular pathogen Gram-negative P. Gingivalis at the pathogenesis of Alzheimer’s disease.“

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Toxins detected before even the symptoms of the disease

Researchers also identified in the brain patients with Alzheimer’s toxic enzymes Called gingipaïnes, produced by P. Gingivalis. These toxins were linked to two key markers of the disease: Tau protein et L’Biquitine. Even more surprisingly. low levels of gingipaïnes have been detected in oral bacteria question? deceased people without diagnosis of Alzheimer’s, which could indicate an early stage of the disease. The authors specify: “Our identification of gingipaine antigens in the brain of people with Alzheimer’s disease. but also in those with pathological signs without Dementia diagnosisshows that brain infection by P. Gingivalis is not due to poor dental hygiene following dementia. advanced stage of the disease, but constitutes an early event that can explain the observed lesions in individuals of average age before cognitive decline.“

A compound developed by Cortexyme, called COR388, showed Murine models that he could reduce the bacterial load in the brain. While reducing the production of beta amyloids and neuronal inflammation. Although the results in humans remain to be confirmed, the scientific community sees it as a cautious hope. As David Reynolds. scientific director of Alzheimer’s Research points out: “The drugs targeting the toxic proteins of this bacteria have so far oral bacteria question? shown beneficial effects in mice, but after more than 15 years without new treatment against dementia, it is essential to test all Possible approaches To fight diseases like Alzheimer’s.“