Ketamine derivatives: two new substances registered on the drug list

Sometimes fatal overdoses

The poisoning linked to these substances have increased in recent years. An investigation report from the Pharmacodependence Addictovigilance (CEIP-A) (Bouches-du-Rhône) report of the declarations. “Between 2017 and 2023, 39 cases were reported: 13 cases are associated with the consumption of O-PCE, 5 cases of DCK and 20 cases with the 2-FDCK. The majority of these cases are serious (66 %), some having required hospitalization, ”specifies the ANSM. The Dramas survey has also identified six deaths related to the analogues of ketamine.

The ANSM highlights a high and potentially fatal overdose risk of overdose, exacerbated by polyconsumption practices. These ketamine derivatives are often consumed with other psychoactive substances. “These molecules are often overlooked and therefore not detected during biological analyzes, exposing consumers to a delay in care during hospitalization or in case of overdose,” adds the health safety agency.

What are the signs of an overdose?

Sensation of discomfort, disorders of consciousness, abnormal movements like convulsions, agitation, delirium of persecution must push a consumer or his loved ones to call for help; 112, 15, 18 or 114 for the hearing impaired.

In the event of repeated consumption, sudden stop can cause withdrawal syndrome; Anxiety, sleep disturbances, urinary complications (which can go as far as renal failure) and liver complications.

To the address of health professionals: “If a patient has an alteration of consciousness, agitation, hallucinations, a delirium of persecution or a dissociative state, without evocative sign of intoxication to opioids, it can be an intoxication to the derivatives of ketamine”.

For any request for help to control or stop your consumption, consult a doctor or a structure specializing in the management of addictions. All information is available on drugs-info-service.fr.

Note: new synthetic products, mimic the effects of already known substances, whether drugs or narcotics, bypassing the legislation. According to the Lille University Hospital, NPS pose great difficulties in the epidemiological monitoring of their use. “Given their permanent renewal, the detection of NPS in entry products, and even more in biological samples (because low circulating concentrations and sometimes intensive metabolism) is a real challenge for analyst toxicologists”.

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Source: Health destination

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