Similarly,
Vitamin d supplementation reduces inflammation:
Chronic liver disease (CLD) is a major global health problem, affecting around 1.5 billion people. Consequently, This potentially fatal disease often progresses in silence, ultimately leading to aggravated affections such as liver cirrhosis or liver cancer. Meanwhile, There is currently no treatment for CLD other than liver transplantation.
Vitamin D is commonly consumed for improved bone health. Meanwhile, This study opens up exciting possibilities to reuse a cheap supplement as a complementary therapy for liver disease. For example, Professor Hyo-Jung Kwon of the College of Veterinary Medicine. Nevertheless, Chungnam National University in Daejeon, Republic of Korea, and his colleagues studied the underlying mechanisms and therapeutic implications of vitamin D in liver disease. Therefore, “” Here we have explored the effects of vitamin D on the canal reaction. In addition, the CLDs and vitamin d supplementation reduces inflammation studied the underlying mechanisms. Our data reveal that vitamin D supplementation improves canal reaction. reduces liver inflammation and largely part fibrosis via TXNIP, ” Communals proficiency. Kwon. Their study was published online on May 13, 2025, in Nature communications.
The canal reaction refers to the proliferation of canal cells (mainly cholangiocytes) in response to liver injury. Although initially protective, an excessive or prolonged canal reaction contributes to inflammation and fibrosis. In this study. researchers observed that plasma levels of lower vitamin D were associated with a more severe canal reaction in patients with CLD.
Vitamin D regulates the expression of Txip (Protein interacting on thioredoxin). This was confirmed in a mouse study where Txip Deleting in cholangiocytes favored canal reaction. even exacerbated liver inflammation and fibrosis. In vitro analysis revealed vitamin D /Txip Molecular axis. “In addition. TXNIP deficiency increases the secretion of TNF-α and TGF-β by cholangiocytes to vitamin d supplementation reduces inflammation stimulate Kupffer cells and hepatic stellate cells, therefore leading to inflammation and collagen deposit”. Add Professor Kwon.
Research that supports early diagnosis and better treatment for CLD is not only justified but essential. “” Our preclinical data reveal a new mechanism by which vitamin D supplementation improves CLDs. supports the idea that the axis of vitamin D / TXNIP could be a promising therapeutic target to tackle the canal reaction clinically and to CLDs, ” Communals proficiency. Kwon. Additional research is necessary to validate the clinical application of vitamin D supplementation as a standard support treatment. for patients with chronic liver disease.
In the end, this work could improve the results for millions worldwide by offering safer and more personalized liver disease.
Vitamin d supplementation reduces inflammation
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