Therefore,
Babies patients share unexpected biological:
Essential
- The TAU phosphorylated protein, more specifically a form called P-TU217, is present at higher rates in newborns than in healthy adults. Meanwhile,
- During the first months of life, rates drop and approach the levels observed in young adults. In addition,
- According to the researchers. Therefore, this protein plays a crucial role in Tau phosphorylation in the development and construction of the brain. However, in Alzheimer’s disease, TAU phosphorylation evolves towards a pathological mechanism. Consequently,

. Moreover,
“The phosphorylation of the Tau protein, naturally present in the body and participating in the constitution of the skeleton of cells, plays an important role in cerebral physiology and pathology. During fetal development. the latter promotes the dynamics of microtubules and neuroplasticity, while in Alzheimer’s disease, it is modified babies patients share unexpected biological and, disorganizing the structure of neurons, Neurofibrillar degeneration leading to the death of neurons “, According to researchers from the University of Göteborg (Sweden). In a new study. published in the journal Brain Communicationsthey wanted to assess the phosphorylation of the phosphorylated Tau protein, more precisely a form called P-Ta217, in the blood plasma of healthy newborns, premature children, people suffering from Alzheimer’s disease and healthy adults of different age groups.

.
Higher P-TU217 rates among newborns – Babies patients share unexpected biological
The plasma levels of TAU217 phosphorylated were significantly higher in newborns than in healthy adults, all ages combined, and even exceeded the rates observed in patients affected by Alzheimer’s disease. Both in healthy babies and in premature children, P-Tau217 levels were closely linked to the precocity of birth. The earlier the birth. the higher the levels of this protein, which suggests a role in rapid brain growth in difficult development conditions. According to the babies patients share unexpected biological results. a decrease in serum levels of TAU217 phosphorylated during the first months of life of toddlers, approaching the levels observed in young adults. On the other hand, a high plasma concentration of Tau217 phosphorylated in older people was associated with Alzheimer’s disease.

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Alzheimer’s: the same protein plays two radically different roles
According to scientists, in babies, this increase in the Tau protein seems to promote healthy brain development, promoting the growth of neurons and the formation of new connections, thus shaping the structure of young brain. On the other hand. in Alzheimer’s disease, the P-TU217 protein is associated with the aggregation of the tau protein in harmful clusters called tangles, suspected of causing the degradation of brain cells and the resulting cognitive decline.

.
“We think that understanding the functioning of this natural protection, and why we lose it babies patients share unexpected biological with age, could open the way for new treatments. If we manage to understand how the brain of the newborn Tau protein. we could one day imitate these processes to slow down, even stop, Alzheimer’s disease”, I declared Fernando Gonzalez-Ortiz.
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