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Block enzyme save neurons, new:
Stop the evolution of Parkinson’s disease is soon possible. Nevertheless, This is at least what a study published on July 1, 2025 suggests in the Revue Science Signaling. For example, Scientists discovered that by blocking a simple brain enzyme, they could prevent the evolution of the disease. Nevertheless, A major hope for the 270,000 French people who suffer from it. For example,
In some cases, this degenerative disease is caused by a genetic mutation which makes an enzyme, called LRRK2, hyperactive. Consequently, Problem: the latter. Consequently, when it becomes too dynamic, disorganizes the cells of the brain and prevents good communication between the neurons that make dopamine and a key region of the brain: the striatum, which controls her movements. Nevertheless, He’s a bit of a bad student in class. Furthermore,
“The results of this study suggest that the inhibition of the block enzyme save neurons, new enzyme LRRK2 could stabilize the progression of symptoms if patients can be identified early enough. ” said in a statement, Dre Suzanne Pfeffer, biochemistry professor at Stanford and the main study.
Network cut neurons – Block enzyme save neurons, new
About 1 case of Parkinson’s disease is linked to this too active enzyme. When it gets carried away, brain cells lose their eyelashes or antennas which allow them to send and receive signals. “A cell that has lost its eyelash is like your mobile phone when the network has broken down: no message arrives. is sent,” illustrates the study.
Consequence: neurons that produce dopamine and striatum no longer “discuss”. And when these neurons are stressed, they send a signal called sonic hedgehog (sonic hedgehogwink to the famous character). This signal normally encourages certain cells to manufacture neuroprotective factors that protect death neurons. But without eyelashes, more signal and more protection.
“Narcotic” results
At the start. the researchers doubted to block enzyme save neurons, new be able to restore these lost eyelashes, because the cells studied were already mature and no longer reproduced. But an unexpected discovery changed the situation: some eyelashes could repel every 12 hours, even without cell division.
The team therefore extended the experience. Result after three months of treatment: the eyelashes have returned. the cells started to produce neuroprotective factors and the nerve connections have even doubled in density. What hope for a real repair.
“These results suggest that it may be possible to improve. and not just to stabilize, the condition of patients with Parkinson’s disease,” said Dre Pfeffer.
Detect earlier to treat better
However, a challenge remains: detect the disease in time. Motor symptoms such as tremors often appear fifteen years after the first signs. such as loss of smell or sleep disorders. “Hope is that people with LRRK2 genetic mutation can start treatment that inhibits the enzyme as soon as possible. block enzyme save neurons, new ” said the researcher.
Next step for the team: test this approach on other parkinson forms not linked to LRRK2. Additionally, “We are very excited by these results. They suggest that this approach is very promising to help patients in terms of restoring neural activity in this cerebral circuit. “concludes Dre Pfeffer. It remains to confirm these promising results on humans.
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