Certain cardiovascular pathologies, such as heart failure, could count among the risk factors of certain cancers … But a metaanalysis suggests that the reciprocal is true: people with history history could present an increased risk of cardiovascular pathology (1).
Cancer history and cardiovascular risk
160 cohort studies, retrospective or prospective, having included a total of nearly 49.4 million individuals (including 9.1 million with cancer history, and more than 40.3 million witnesses) were analyzed in this work, which is a cardiovascular risk generally increased by 47 % in cancer survivors, compared to witnesses.
If an overview emerged for 17 subtypes of cardiovascular disease examined, patients with history of cancer appeared particularly at risk of thromboembolic disease (HR = 3.07).
Certain types of cancer also seemed particularly deleterious for cardiovascular health: brain, hematological, respiratory, male and breast genitals. Young, male patients also appeared very vulnerable.
HSCRP level and risk of long -term myocardial infarction
In addition, with regard to patients hypertensive already under preventive, and apparently stable treatment, a study published in the journal eBioMedicine suggests an interest in the dosage of the high sensitivity protein C-Reactive (HSCRP) to improve management (2).
According to this post-hoca analysis of the Anglo-Scandinavian ASCOT trial, conducting with 5,294 English under antihypertensives or hypolipidemating drugs followed for 20 years, and having benefited from a dosage of HSCRP during their recruitment, high rates of HSCRP can independently predict the risk of cardiovascular events and the mortality in the long term stables with hypertension.
Compared to patients with the lowest HSCRP levels, those who manifest the highest concentrations of HSCRP would have a myocardial infarction of 32 % at 20 years, and a risk of death in all increases increased from 25 % to 20 years. Note that this biomarker did not seem reliable, however, to predict the risk of stroke.
Intestinal microbiota and secondary cardiovascular risk prevention
Finally, the digestive microbiota has been the subject of an increasing number of research in recent years. Certain microbial composition profiles of the intestinal flora could make it possible to refine the estimate of the risk of major cardiovascular events (MACE) in secondary prevention.
This is the conclusion of the Cordioprev clinical trial (3), published in l’European Heart Journal. C This work, which determined the microbial composition of sample samples 679 patients already taken care of for cardiovascular disease, suggests that the presence of a dozen types of bacteria and an increase in the rate of post-Prandial LPS would be associated with a doubling of the risk of MACE in secondary prevention.
Better predict the risk of cardiovascular complications after acute respiratory infection
Acute respiratory infections are known to increase in the short term the risk of myocardial and stroke infarction. No tool currently allows this routine risk to predict. A gap that British and Cypriot researchers wanted to fill by developing an estimate of the risk of cardiovascular events likely to occur within 28 days of the start of an acute respiratory infection (4).
To do this, the authors have looked into electronic health files over 6 million English over 40 years without particular cardiovascular history and having had a diagnosis of respiratory infection between 1999 and 2019, of which 18,000 proved to have developed cardiovascular complications within 28 days.
Ultimately, the score, called Dashi, makes it possible to calculate this risk according to the age of the patient, the underlying presence of a diabetes, smoking or symptoms of heart failure, and the type of respiratory infection-those reaching the low respiratory tract appearing the most impactful.
(1) Qian Lia, Guofu Zhang, Xiating Li, et al. Risk of cardiovascular disease among cancer survivors: systematic review and meta-analysis. eClinicalMedicine. Volume 84. 103274. June 2025
(2) Adam Hartleya, Somayeh Rostamiana, Amit Kaura, et al. The relationship of baseline high-sensitivity C-reactive protein with incident cardiovascular events and all-cause mortality over 20Â years. eBioMedicine. Volume 117. 105786. July 2025
(3) Javier Arenas-Montes, Juan F Alcala-Diaz, Helena Garcia-Fernandez, et al. A microbiota pattern associated with cardiovascular events in secondary prevention: the CORDIOPREV study. European Heart Journal, Volume 46, Issue 22, 7 June 2025, Pages 2104–2115
(4) Joseph J. Lee, Constantinos Koshiarisa, Cynthia Wright-Drakesmith et al. Development and external validation of a risk prediction score (DASHI) for cardiovascular events following acute respiratory infections: derivation and validation retrospective cohort study. eClinicalMedicine. Volume 84. 103273. June 2025
