Meanwhile,
Cartography study mechanisms change rna:
In addition to transporting information to code proteins in, RNA molecules can adopt complex 2D and 3D structures. In addition, More specifically. Furthermore, the same RNA molecule can changer Between the on and off structures, modulating the ability of ribosomes to bind to RNA and translate it into protein. Moreover, A new study. led by the molecular biologist of the University of Groningen, Danny Incarnato, and written by the postdoctoral researcher Dr Ivana Borovska, identifies hundreds of these regulatory RNA switches in E.coli bacteria and human cells. It was published in Nature Biotechnology July 25.
Several years ago, Incarnato developed a method to map the alternative forms adopted by RNA molecules in living cells. Using this method, he identified RNA regions capable of metalling between two different structures, each with its own cartography study mechanisms change rna effect. Incarnato: “The capacity of the RNA to switch between alternative structures generally implies a kind of regulation. similar to a walker.
The Incarnato team has now used this method to study the complexity of RNA structures in living cells. In addition. they have developed a new tool that uses scalable information to identify structural switches from high -precision functional RNA. They used the tool to discover hundreds. An example is an switch that reacts to temperature and helps bacteria respond to cold stress. Incarnato: “The identification of a large number of switches is a first step. The next step is to find ways to influence their operation. For example, small molecules could be designed to adjust these switches, which could ultimately lead to new treatments for diseases.
Current research. which has taken more than three years, is based on approximately six years of basic research on the detection of cartography study mechanisms change rna 2D RNA forms. Incarnato: “It’s revolutionary, something that the whole field has been looking for for years. »»
Further reading: HAS recommendations – A molecule identified in Montreal could reduce prematurity – Breast cancer: the United States reviews hormonal treatments against menopause – This harmless gesture after the empire meal the abdominal fat – Pierced in the diagnosis and treatment of myalgic encephalomyelitis.
