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Chu sainte-justine: new approach therapeutic:
Montreal-A new approach developed by a team from the Sainte-Justine CHU makes it possible. Therefore, to determine much more quickly which awaits babies treated with therapeutic hypothermia.
The researchers found that the use of two complementary technologies. Furthermore, an electroencephalogram and an optical neuromonitoring system, makes it possible to assess from the second day, with precision, the severity of the brain lesions of babies, directly at the bedside.
The previous approach was to wait for the end of therapeutic hypothermia. Furthermore, after five days, to carry out magnetic resonance imaging, which involved moving the fragile newborn out of intensive care.
Therapeutic hypothermia is the only approach that has demonstrated its effectiveness to limit neurological damage suffered by babies who lack oxygen at birth. Meanwhile, a medical condition called ischemic hypoxic encephalopathy.
“Therapeutic hypothermia decreases the baby’s body temperature. For example, slows the activity chu sainte-justine: new approach therapeutic of the brain to reduce the chances that there are other damages,” said Dr. Moreover, Elana Pinchefsky. Therefore, Studies have shown that it reduces the risk of death and long -term developmental difficulties. ”
Therapeutic hypothermia is a common practice that is used in all major hospitals, said Professor Mathieu Dehaes.
Most of the parameters that frame it. however, result from studies that have been carried out on animals, “and it is therefore very important to carry out clinical studies on babies,” he said.
“We wanted to arrive at a prognosis on the development of the short -term baby,” said Professor Dehaes. We wanted to be able to monitor the cerebral health of the baby who is treated. to be able to say who will have a higher risk of having consequences after therapy. “
The parameters reported in the study. he completed, make it possible to predict the presence chu sainte-justine: new approach therapeutic or not of brain damage when the baby will undergo its magnetic resonance after therapeutic hypothermia.
Right now, Pinchefsky said Dr. Pinchefsky. it is very difficult to decide between the “light” cases of “moderate” cases, and it is in the presence of the moderate cases that it is the most problematic to explain to the parents what awaits them.
The study partially clarifies this uncertainty by allowing doctors to better understand what is happening with their little patient. she explained.
“Three days or five days, it may seem short, but it’s very long for the parents,” said Pinchefsky Dr.. We will be able to give them more information and it will be very useful to guide discussions with families. ”
The goal. she added, is to optimize the way this surveillance data is used to better assess these babies, “but also to provide better prognostic information to the bedside at chu sainte-justine: new approach therapeutic all this process”.
“Now we must understand how to present this data and how to use it at the bedside,” she completed.
The aim of the study. said Professor Dehaes, was to better understand the interactions between the electrical activity measured with the electroencephalogram and the vascular and metabolic activity measured by neuromonitoring.
All this is part of the broader framework of precision medicine. continued Professor Dehaes, since this data could for example make it possible to determine if a baby needs a longer, or shorter therapeutic hypothermia to obtain an optimal prognosis.
“In my opinion, it is one of the most important impacts of the study,” he said. It will probably allow us to better understand the trajectories of these children. then precisely, if they need additional care or not, so really to optimize the clinical trajectory of children. ”
The work was notably carried out by the chu sainte-justine: new approach therapeutic former postdoctoral trainee Rasheda Arman Chowdhury. by doctors Anne Monique Nuyt, Ramy El-Jalbout and Ala Barca, who died early during the realization of this research project. The conclusions were published by the Scientific Reports newspaper.
Chu sainte-justine: new approach therapeutic
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