Furthermore,
Hypothalamic neurons help maintain blood:
The brain controls the release of glucose in a wide range of stressful circumstances. Similarly, including fasting and low blood sugar.
However, less attention was paid to its role in daily situations.
In a study published in Molecular metabolismResearchers at the University of Michigan have shown that a specific population of. In addition, hypothalamus neurons help the brain maintain blood sugar in routine circumstances.
Over the past five decades. Moreover, researchers have shown that dysfunction of the nervous system can cause blood sugar fluctuations, especially in diabetic patients.
Some of these neurons are in the ventromedial nucleus of the hypothalamus. a region of the brain which controls hunger, fear, temperature regulation and sexual activity.
“Most studies have shown that this region is involved in blood sugar farming during emergencies,” said Alison Affinati, hypothalamic neurons help maintain blood MD, PH.D., assistant professor of internal medicine and member of Caswell Diabetes Institute.
“We wanted to understand if it is also important to control blood sugar during daily activities. because this is where diabetes develops. »»
The group focused on VMHCCKBR The neurons, which contain a protein called receptor of cholecystokinin B.
They used mouse models in which these neurons were inactivated.
By monitoring blood sugar. researchers discovered that VMHCCKBR Neurons play an important role in maintaining glucose during normal activities, including the first part of the fasting period between the last meal of the day and the awakening in the morning.
“During the first four hours after lying down. these neurons assure you that you have enough glucose so that you do not become hypoglycemic overnight,” said Affinati.
To do this, neurons order the body to burn fat by a process called lipolysis.
The fats are broken down to hypothalamic neurons help maintain blood produce glycerol, which is used to make sugar.
When the group activated the VMHCCKBR Neurons in mice, animals had increased glycerol levels in their bodies.
These results could explain what is happening in patients with prediabreaking because they show an increase in lipolysis overnight.
Researchers believe that in these patients, VMHCCKBR Neurons could be hyperactive, contributing to higher blood sugar.
These nerve cells, however, only controlled lipolysis, which raises the possibility that other cells control glucose levels by different mechanisms.
“Our studies show that glucose control is not a switch on the point where thought previously,” said Affinati.
“Different neurons work together, and everything lights up in an emergency. However, under routine conditions, it allows subtle changes. »»
The team works to understand how all the neurons of the ventromedial nucleus coordinate their functions to regulate sugar levels in different conditions. including fasting, diet and stress.
They are also interested hypothalamic neurons help maintain blood in understanding how the brain. the nervous system affect the body of the body together, especially in the liver and the pancreas.
The work was carried out by a team of UM researchers at Caswell Diabetes Institute which focuses on the neural control of metabolism – the roles played by the brain. the nervous system in metabolic control and disease.
Hypothalamic neurons help maintain blood
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