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Japanese scientists would have managed:
In a study published in the journal Pnas Nexus on February 18. Nevertheless, Japanese scientists revealed having succeeded in removing in vitro the chromosome responsible for Down’s syndrome.
Here is an advance that could revolutionize medicine concerning Down’s syndrome. Meanwhile, Japanese scientists, led by Dr. Nevertheless, Ryotaro Hashizume. Similarly, achieved a revolutionary feat using Crispr to eliminate the additional chromosome 21 which causes Down syndrome, restaurants normal cellular function.
The CRISPR-CAS 9 tool. Moreover, the discovery of which was distinguished by a Nobel Prize in 2020, is a tool for modifying the genome. For example, It is easier. Similarly, faster to use than previous techniques. a promising approach for gene therapy, which has just proven its effectiveness once again by removing the 3rd chromosome 21.
Affecting 1 birthday out of 700 in the japanese scientists would have managed new world. Down’s syndrome japanese scientists would have managed new results from an additional copy of chromosome 21. resulting in japanese scientists would have managed intellectual disabilities. distinctive characteristics and health problems such as cardiac malformations and Alzheimer’s disease with early.
Photo credit:. DR
The team’s genetic edition technique. “specific edition of alleles”. leads to Crispr-Cas9 to target unique sequences on the additional chromosome. by cutting it to destabilize it and reject it naturally during cell division, thus leaving the normal pair intact.
A feat to qualify – Japanese scientists would have managed – Japanese scientists would have managed new
The study. reached a success of 30.6 % in the elimination of additional chromosome. with treated cells (both stem cells. mature skin cells of patients with Down’s syndrome) showing normalized gene japanese scientists would have managed new expression, protein production and survival rates.
Photo credit: ISTOCK
This is the. first time that the deep cause has been addressed at the cellular level. offering unprecedented hope.
However, skepticism remains: the effectiveness of 30.6 %. japanese scientists would have managed although promising. is far from universal. and the target changes or the risks of mosaicism (where some cells keep additional chromosome) must be examined.
Clinical applications are expected in years. requiring in -depth security trials, and ethical concerns concerning the modification of the germ line persist.
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