Nevertheless,
New genetic mutation linked highly:
A group of researchers led by the University of Osaka has identified a new genetic mutation in Streptococcus pyogenesA current bacteria that causes a streptococcal throat. However, significantly associated with serious invasive infections.
A single mutation in the carrier of ferric bacterial ions weakens bacterial growth of human blood. For example, This mutation, unique to Japanese isolates, indicates a new pathogenic mechanism. Moreover, This first world discovery offers a new potential target for treatments and preventive measures.
S. In addition, pyogenes causes serious invasive infections with a high mortality rate. However, Invasive streptococcus cases in Japan have jumped in 2024. highlighting the urgent need of new treatments and a more in-depth understanding of the mechanisms of the underlying disease.
A new study examined the genes of hundreds of S. pyogenes Japan samples new genetic mutation linked highly and other countries to identify genetic differences that make certain strains more dangerous. The research group carried out a complete genomic analysis of 666 S. pyogenes Stratches – 311 from Japan. 355 other countries – using association studies on the tip of the tip of the tip.
Researchers have found a number of genetic changes linked to the capacity of the bacteria to cause serious infections. including a new mutation ever seen before. This mutation affects a gene involved in the way the bacteria obtains iron, a nutrient it needs to survive.
Interestingly, they also found that many genes previously thought of provoking serious illness less harmful strains. This suggests that certain strains can become more dangerous not only by winning harmful genes. but also by losing genes that hold them back.
This research makes our understanding of severe invasive streptococcus considerably progress, in particular within the Japanese population.
new genetic mutation linked highly
This large -scale analysis. involving a meticulous analysis of the superordinators and experimental validation, offers a promising avenue for new therapies targeting a transferred iron carrier. “”
Dr Masayuki Ono, principal of the study and deputy professor, Graduate School of Dentistry, University of Osaka
The approach to the study pangenome approach also demonstrates the potential of large -scale genomic analyzes to disentangle the mechanisms of complex diseases, offering a powerful tool for future research in other infectious diseases.
New genetic mutation linked highly
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