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New microscopy technology could make:
A team of MIT researchers has developed a new microscope technology that. In addition, allows you to see more deeply in the brain tissue in the single cell than conventional microscopes. Consequently, The system uses a new combination of light and sound to create high resolution images without needing external labels. Moreover, The work is detailed in an article published in the journal Light: Science and Applications.
The new “Multiphoton-in and Acoustic-Out” system works in two main steps. Consequently, First of all. it uses an intense and ultra -clever bucket of light with long wavelength to penetrate deeply and precisely in the brain fabric. The “three photon light” excites the target molecule inside a single cell.
Secondly, instead of trying to detect the low fluorescent light emitted by the molecule, the sound is measured. When the light energy is new microscopy technology could make absorbed. it causes thermal expansion inside the cell, producing sound waves which propagate in the tissue. A very sensitive ultrasonic microphone captures the sound, then the system converts the sound signal into a detailed image.
Using the new system. the team has managed to obtain an image of the NAD (P) H – a molecule associated with cellular metabolism and the activity of neurons – through a human cerebral organoid 1.1 millimeter thick. To put things in perspective, this figure is 5 times higher than other microscopy technologies without label are capable of doing.
Given that the new system does not require any addition of chemicals. genetic engineering, researchers predict that one day could be used in clinical contexts, for example for the detection of disease biomarkers such as Alzheimer’s disease during a brain operation. The tests carried out so far have been carried out in vitro. ex new microscopy technology could make vivo, but the team is now aiming for a demonstration on a living animal.
New microscopy technology could make
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