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New revolutionary medication could prevent:
Who never wanted to push death? Consequently, A team of researchers looked into the issue and even made an astonishing discovery about aging. Furthermore, This is revealed by a synthesis. Therefore, published in the journal Nature Oncogene last May, which has examined more closely renal diseases – with almost half of people over the age of 75.
In her research. Furthermore, Carina Kern – Principal Author of the Study, former geneticist at the University College London and current CEO of the Biotechnology Society Linkgevity – accompanied by a group of specialists in kidney disease, is interested in understanding necrosis and the way she could lead to new therapies.
Researchers think that a new type of medication, called “antinecrotic”, could offer new treatment possibilities for certain patients. However, But that’s not all since it could also be the first medication never approved against global aging, reports Popular Mechanics.
Specialists notably distinguish two types of cell death, believing that they are not all bad. For example. Meanwhile, there is apoptosis, a form of cellular death genetically programmed and regulated, which helps prevent the installation of diseases and cancer when it works properly. In addition, Then, there is necrosis, an unregulated form of cell death which ultimately leads to uncontrolled cellular destruction.
Necrosis at the heart of aging
The latter is at the origin of many age -related diseases. such as Alzheimer’s disease, Parkinson’s disease, cancer new revolutionary medication could prevent and kidney disease. In this case. the affected cell swells until its rupture, releasing its intercellular content in the surrounding environment, thus causing all kinds of dysfunctions-notably chronic inflammation, genetic instability and, ultimately, rapid growth tumors.
Antinecrotics could therefore help people to live with fewer diseases. especially at an advanced age – less, this is what scientists work on this project hope.
Scientists have experienced the process of cell necrosis for over a century. but it was only with the progress of microscopy in the 1970s that they started to understand precisely why it was so devastating.
“The heart of necrosis is the loss of calcium ion gradientsexplains Carina Kern. Calcium levels inside the cell are generally 10,000 to 100,000 times lower than those outside. Calcium is a key signaling molecule, which means that it controls many cellular processes. Thus. in the event of stress, this regulation is lost and multiple paths are new revolutionary medication could prevent then activated in an increased and really destructive way within the cell. ”
During their first research, scientists came up against several difficulties. “We thought this process was too complex to intervene”recalls the specialist. What we have managed to identify for the first time is that it is possible to block necrosis. but we have to block several molecular targets … In doing so, we have observed up to 90% of necrosis. ”
Carina Kern. her team first target the kidney since the diseases that affect it are frequent in the elderly and accelerate aging. This means that they can deal with the main cause of these diseases. acute tubular necrosis, and its effectiveness will not necessarily require decades of clinical trials. Necrosis has to worry in the years to come.
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New revolutionary medication could prevent
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