Essential
- The prediabetes is initially associated with mortality, but the link no longer existed once the demographic variations, the factors linked to the lifestyle and the comorbidities taken into account.
- This disorder was statistically significantly linked to mortality in adults aged 20 to 54.
- The early appearance of health problems in this group could reflect stronger genetic predispositions, resulting in faster progression of the disease and more serious health consequences.
“In addition to the increase in the risk of developing type 2 diabetes, prediabetes, characterized by blood sugar between 1.10 and 1.25 g/, is also linked to an increased risk of cardiovascular disease and high mortality, all causes combined and by cause. However, the association between prediabète and mortality remains complex, especially when it is made of factors, and comorbidities “, According to researchers from the University of Buffalo (United States).
People aged 20 to 54 suffering from prediabetes are more likely to die
In order to better understand the impact of these factors on this link, the latter carried out a study during which they analyzed the data of the National Survey on Health and Nutrition (Nhanes), carried out by the centers for the control and prevention of diseases (CDC). Information from 38,093 people over the age of 20 was examined. Among them, 9,971 were prediabetic. In detail, the participants were considered to be prediabetic if they declared to be or if their hemoglobin A1C, an average of blood sugar over three months, was between 5.7 % and 6.4 %. Associations were evaluated by adjusting three levels of factors: demographic factors alone, demographic factors and linked to lifestyle, and demographic factors, linked to lifestyle and comorbidities.
The results, published in the journal JAMA Network Openhave shown a link between prediabetes and mortality before the authors take into account demographic variations, factors linked to lifestyle and comorbidities. But once these factors are taken into account, the association has disappeared. “However, we found that the significant relationship between prediabetes and mortality was maintained after adjustment when the analysis focused on adults aged 20 to 54,”, said Obinna Ekwunife, who led the work.
“Pre -division in younger adults reflects a more harmful evolution of the disease”
According to scientists, it is possible that the elderly may be more likely to present existing comorbidities, so that these chronic diseases can mask the impact of the prediabetes. “Another possibility is that prediabetes in younger adults reflect a more harmful evolution of the disease, with an earlier appearance of metabolic disorders. Additional hypotheses could explain this association: a stronger genetic predisposition, resulting in faster progression of the disease, as well as health disparities, such as reduced access to care or less participation in regular preventive care in patients.
Tailor -made diabetes prevention programs targeting younger adults
“Whatever the cause, the results underline the need to pay increased attention to the prediasered prediably detection and management in younger adults. This would be particularly important for those with additional risk factors such as obesity, family history of diabetes or socio-economic difficulties.” The work also highlights the importance of adapting diabetes prevention programs so that they are more accessible and attractive for younger adults.
