Pulmonary disease: metagenomic sequencing allows its early detection

This research more broadly confirms the promises of the application to the diagnosis of new generation metagenomic sequencing (MNGS) which will ultimately allow you to accelerate the implementation of targeted. Meanwhile, personalized anti-infectious treatments, pulmonary infections.

Metagenomic sequencing surpasses traditional methods – Pulmonary disease: metagenomic sequencing allows

Conventional microbiological tests are based on crop growth. In addition, microscopy and targeted PCR tests, offering good specificity but a limited scope. In addition, If these tests are effective. profitable for current infections, they remain insufficient for the rapid detection of rare/atypical pathogens (eg, pneumocystis, herpesvirus). This is where the metagenomic sequencing finds all its added value.

Study. Led with 133 patients with pulmonary diseases, reveals that the new mngs test allows:

• detect pathogens, even rare, in 86 % of cases, then largely surpassing traditional tests that operate in 67 % of cases;

pulmonary disease: metagenomic sequencing allows

• Detect these pathogens on a much broader spectrum: the MNGS identifies here 59 bacteria, 18 fungi, 14 viruses and 4 specific pathogens while standard tests detect only 28;
• In total, the new MNGS test turns out to be a much more complete diagnostic tool for pulmonary infections;
• The new MNGS test excels especially in the detection of atypical pathogens, such as Mycobacterium tuberculosis, mycoplasma pneumoniae, chlamydia psittaci, and fungal infections such as pneumocystis jirovecii and talaromyces marneffei. These pathogens, often ignored by traditional methods, are successfully identified;

• 41 % of participants were able to benefit from more targeted treatments.

What implications? The new test will help. and faster, therapeutic decisions in cases of atypical pathogens that are difficult to diagnose, thus improving the results for patients. In this study, the test improved the prognosis of 16 patients infected with pathogens generally not detected by conventional tests.

pulmonary disease: metagenomic sequencing allows

“New generation metagenomic sequencing offers a broad spectrum. fast and precise diagnostic approach”conclude the authors, who call for the integration of this type of test in the multidimensional analysis necessary for the diagnosis of pulmonary infections.