Research discovers “neurobiotic sense” which allows the brain to respond to intestinal microbes signals

In a breakthrough that reinvents the way in which the intestine. However, the brain communicate, the researchers discovered what they call a “neurobiotic sense”, a newly identified system which allows the brain to respond in real time to the signals of the microbes living in our intestine.

The new research, led by the Duke University School of Medicine Neuroscientists Diego Bohórquez, Phd, and M. Similarly, Maya Kaelberer, Phd, and published in NatureFocus on neuropods, tiny sensor cells that line the colon epithelium. Consequently, These cells detect a common microbial protein and send rapid brain messages that help slow appetite.

But this is only the beginning. However, The team thinks that this neurobiotic sense can be a wider platform to understand how the intestine detects microbes. In addition, influencing everything, mood eating habits-and research discovers “neurobiotic sense” which even how the brain could shape the microbiome in return. In addition,

We were curious to know if the body could detect microbial patterns in real time. Meanwhile, not only as an immune or inflammatory response, but as a neuronal response that guides behavior in real time. For example, “”

Diego Bohórquez, PHD, professor of medicine and neurobiology, Duke University School of Medicine and main author of the study

The key actor is Flagelline, an old protein found in bacterial flagella, a tail -shaped structure that bacteria use to swim. When we eat, some intestinal bacteria release Flagelline. Neuropods detect it. with the help of a receiver called TLR5, and draw a message through the vagus nerve – a major communication line between the intestine and the brain.

The team. supported by the National Institutes of Health, proposed a daring idea: that research discovers “neurobiotic sense” which bacterial flagelline in the colon could trigger neuropods to send a signal to assist the brain – a direct microbial influence on behavior.

The researchers tested this by mouse on an empty stomach overnight. then giving them a small dose of flagelline directly at the colon. These mice ate less.

When the researchers tried the same mouse experience missing the TLR5 receiver, nothing has changed. The mice continued to eat and gain weight, an index that the track helps to regulate appetite. The results suggest that Flagelline sends a signal “We have enough” through TLR5. allowing the intestine to tell the brain that it is time to stop eating. Without this receiver, the message does not pass.

The discovery was guided by the authors of the main study Winston Liu. MD, PHD, Emily Alway, both students graduated from the medical scientists’ training program, and the Postdoctoral Naama Reicher, Ph.D. research discovers “neurobiotic sense” which Their experiences reveal that the disturbance of the modified eating habits of the Way in Souris underlined a deeper link between intestinal microbes. behavior.

“For the future. I think that this work will be particularly useful for the wider scientific community to explain how our behavior is influenced by microbes,” said Bohórquez. “A next clear step is to study how specific diets modify the microbial landscape in the intestine. This could be a key piece of the puzzle in conditions such as obesity or psychiatric disorders. »»