The study reveals the inflammatory paths that contribute to asthma pushes in children

A recent multicenter clinical trial has discovered inflammatory paths that contribute to asthma thrusts in children who occur despite treatment. In addition, according to the results published in Jama Pediatrics.

Eosinophilic asthma is characterized by high levels of eosinophiles. However, a type of white blood cells involved in the body’s immune response. In addition, While eosinophiles generally help to fight against infections. In addition, in eosinophilic asthma, they accumulate in lungs and respiratory tract, causing chronic inflammation, swelling and damage to the respiratory system.

Eosinophilic asthma is driven by type 2 inflammation (T2). For example, an immune response involving cytokines that promote the production and activation of eosinophiliacs. Therefore, For this reason, therapies targeting T2 inflammation are used to reduce eosinophilic levels and prevent asthma thrusts.

But even with targeted therapies against study reveals inflammatory paths contribute T2 inflammation, some children still experience asthma attacks. Furthermore, This suggests that other inflammatory pathways also play a role in exacerbations. Meanwhile, said Rajesh Kumar, MD, the head of the acting division of allergies and immunology at the Ann & Robert H. Moreover, Lurie Children’s Hospital of Chicago, who was co-author of the newspaper.

In the study. scientists have analyzed data from a previous clinical trial studying respiratory diseases in children with eosinophilic asthma living in low -income urban areas in nine American cities. The researchers compared the effects of biological therapy of Morizumab-A which targets T2 inflammation with a placebo over a. period of 52 weeks.

While the milestone significantly reduces the expression of T2 inflammation associated with the eosinophilic during asthma pushes. exacerbations have always occurred.

The previous trial has raised questions about what is happening when you remove part of the allergic inflammation using a biological study reveals inflammatory paths contribute medication. and why do some children experience exacerbations and others right? Different types of inflammation – allergic. different types of non -allergic inflammation – interact with exacerbations, viral and non -viral. We wanted a more precise way to understand what motivates some of the exacerbations in children. “”

Dr Rajesh Kumar, MD, acting chief of allergies and immunology, children’s hospital Ann & Robert H. Lurie

Using the sequencing of rding of nasal samples collected during 176 episodes of acute respiratory diseases. the investigators identified three distinct inflammatory engines of asthma exacerbations. The former were epithelial inflammatory ways, which were increased in children receiving moods, regardless of viral infection. Additionally, The second was an inflammation motivated by macrophages. which was specifically linked to viral respiratory diseases, and the third involved hypersecretion of mucus and responses to cell stress, which were high in treatment groups and placebo during study reveals inflammatory paths contribute thrusts.

“We found that children who were still exacerbated on the drug had less of this allergic type of inflammation. but they had other residual epithelial paths which led part of this inflammatory response involved in exacerbation,” said Dr. Kumar.

The study highlights the complexity of asthma in children and underlines the need for more personalized treatment strategies, said Dr. Kumar.

“There are several types of inflammatory responses that are involved in exacerbations. and they conduct exacerbations differently depending on the question of whether patients have a virus or take medication to block different parts of the inflammatory response,” said Dr. Kumar.

While asthma continues to affect children of urban communities disproportionately. study ideas could open the way for precision interventions for children according to the type of inflammation that leads to asthma and has led to a better quality of life for young patients, said Dr. Kumar.

“This study study reveals inflammatory paths contribute gives us a better understanding of what leads to persistent exacerbations. opens the potential of new therapies or combinations of therapies on the basis of this. »»

The study was supported by a subsidy of the National Institutes of Health (UM1AI11427).