Are they more exposed to alcoholism?

Retain – They more exposed alcoholism?

• In a cohort From 1,897 patients with bipolar disorder, 48.9 % report pain.
• The prevalence of alcohol history increases significantly with pain: 23.2 % in painless patients and 43.4 % in those with pain (p <0.001).
• This pain-alcoholism relationship in the bipolar patient would be mediated by levels of depression, anxiety and affective lability.

Methodology – They more exposed alcoholism?

• A cohort of 1,897 ambulatory patients with type I or II bipolar disorder was recruited in 16 expertise centers in France, with evaluation of the history of disorders of the use of current substances and symptoms.
• The intensity of the current pain was categorized using an item of the EQ-5D-5L scale in 4 levels: absence of pain, light pain, moderate pain, and severe they more exposed alcoholism? or extreme pain.
• The researchers carried out bivariate analyzes to test the associations between the level of pain and other variables, followed by a multiple regression to characterize individuals with bipolar disorder, pain and disorders of the use of relevant substances.
• An analysis was carried out to examine whether clinical variables could explain the associations between pain and disorders of the use of identified substances.

Main results

• The intensity of pain was significantly associated with the history of alcohol consumption disorder, with an increasing prevalence ranging from 23.2 % in painless patients to 43.4 % in those reporting severe extreme pain (p <0.001).
• Patients with alcohol consumption disorder and extremely moderate pain had an increased risk of panic disorder (odds ratio [OR] they more exposed alcoholism? 3,1 [1,9-5,1]) and anxious disorder (gold 2.7 [1,7-4,3]).
• The analysis of patients revealed that the association between alcohol consumption disorder and pain was mediated by the current levels of depression (β = 0.01; p = 0.007), affective lability (β = 0.13; p = 0.004) and anxiety (β = 0.012; p <0.001).

In practice

Bipolar disorders relate to 2.4 % of the population, and affected individuals are twice as much risk of suffering from pain than non -bipolar. Bipolar patients are more likely to smoke (up to 60 %), to have substance consumption disorders (51.1 % in men and 34.4 % in women). Bipolarity and addictions share a common vulnerability aggravating the patient’s prognosis. Associations between pain and addictions in bipolar patients remain poorly understood because it is not very studied. Hence the interest of this study. The authors evoke that their results underline they more exposed alcoholism? that ” Although the relationship between disorders linked to current alcohol consumption. current pain is well known to practitioners, these results suggest that they do not neglect the history of addictive disorders in bipolar patients, as they could indirectly explain the pain of the individual »In particular via their link to anxio-depressive disorders.

Main limitations

The use of multiple statistical tests could have led to false negatives. particularly concerning the disorders of the use of substances other than alcohol. The evaluation of pain by the EQ-5D-5L scale measured only the intensity of the pain at the time of maintenance. preventing any chronological inference. The population studied came from French expertise centers in bipolar disorder, which could limit the generalization of results. In addition. information on the active consumption of substances in the days preceding the evaluation was not available, which could have influenced the they more exposed alcoholism? experience of pain.

Funding. interest links

The study was funded by the public assistance of Paris hospitals, the Fundamental Foundation, the Investments for the Future, ANR and Inserm program. Over the past 5 years, R. Icick has received advantages corresponding to 10 meals during presentations of Camurus SAS concerning treatment with Buprenorphine and Methadone. B. Etain was a consultant for Sanofi. The other authors do not declare any conflict of interest with this study.

This article was created using several editorial tools, including AI, as part of the process. The editorial team saw this content before its publication.