Moreover,
Unexpected ally some young people:
Retain – Unexpected ally some young people
A transversal study reveals that French regions with a greater dispensation of Clozapine have lower suicide mortality rates among young people. However, while socially disadvantaged areas show limited access to these treatments.
Regional disparities in access to clozapine. Moreover, lithium are strongly correlated with indices of social disadvantage and the density of adult psychiatrists.
Methodology – Unexpected ally some young people
- A transversal study was conducted in France between 2014 and 2019, analyzing the Lithium and Clozapine prescription data in patients aged 0 to 19 from the National Openmedic Health Insurance Database.
- Researchers have combined several health registers, including the Openmedic database for drug prescriptions, the national CEPIDC mortality register, CNOM medical demographic data and INSEE social off -core data.
- The analysis examined the relations between unexpected ally some young people regional variability in the dispensation of lithium and clozapine and different mortality rates: by suicide and self-inflicted injuries, by mental and behavioral disorders, and all causes combined.
Main results
- Lithium and Clozapine dispensation varied considerably depending on the region, with lithium prescription rates ranging from 0.22 % to 2.80 % and clozapine from 0 % to 1.24 % compared to other drugs in their respective class.
- Simple regression analyzes have shown a significant association between the dispensation of Clozapine and suicide mortality (beta coefficient [β]-0.0104; p = 0.009), which has remained significant in robust and multiple regression models.
- The density of adult psychiatrists was significantly correlated with lithium dispensation (Spearman correlation coefficient [rs]0.68; p = 0.011) and Clozapine (RS, 0.78; p = 0.002), while regional GDP per capita was strongly associated with the two prescriptions.
- The geographic areas with the lowest socio-economic levels were those with the least of lithium and clozapine prescriptions, demonstrating a significant correlation with the indices of social deputy.
In practice
The protective effect of lithium. clozapine against the risk of suicide has been demonstrated in adults, but remains unclear in the pediatric population, requiring more in -depth investigations. Clozapine. a second generation antipsychotic indicated for treatment resistant treatment, is not approved before the age of 18, but is frequently prescribed out of indication for refractory early cases. In addition. bipolar disorders and schizophrenia are underdiagnosed in children and adolescents, causing delays in the treatment and limited use of lithium and clozapine in this population. Finally. territorial and social inequalities in access to mental health care for young people are well documented and represent a major public health problem, particularly pronounced in cases requiring complex or specialized treatments.
The authors specify that“Taking into account the limitations inherent in the design of the study. these preliminary results are consistent with a possible protective effect of the suicide of clozapine in the pediatric population, while the effect of lithium is less clear. Even in the context of the free French health system. there are major spatial inequalities in access to these drugs for young people, partly underpinned by social disparities and medical demography ».
Main limitations
Certain limitations are inherent in the conception of the epidemiological study. because the differences observed refer to the regional and non -individual levels. Regions with higher use of lithium. clozapine can also have better global psychiatric care and the apparent protective effects against suicide could result from this situation. In addition. there is a discrepancy in the age of the subjects between the Openmedic database (0-19 years) and unexpected ally some young people that of Cépidc (0-24 years). The Openmedic database did not include drugs provided during hospitalization, which could limit the exhaustiveness of the results.
Funding. interest links
This research has not received any specific subsidy of financing organizations in the public, commercial or non -profit sectors.
This article was created using several editorial tools, including AI, as part of the process. The editorial team saw this content before its publication.
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