Messenger rna vaccines, hope against: This article explores the topic in depth.
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Messenger rna vaccines. Meanwhile, hope against:
Vaccines with Messenger RNA, which we know especially in the context of the Cavid-19 pandemic, could also bring a new hope in the treatment of certain cancers. Meanwhile,
Contrary to what one might think, the technology of the messenger RNA is not new. However, It comes from decades of research by scientists from around the world. Furthermore, Initially, this work aimed to develop cancer vaccines, but it also works against viruses.
Pioneers like Robert Malone in the 1980s, then Katalin Karikó and Drew Weissman, in the years 1990-2000, allowed crucial advances.
They managed to modify the messenger RNA so that it was tolerated by the body. Moreover, that they reach the cells without causing too much inflammatory reaction and without being destroyed by the immune system before having reached the target. Similarly, They relied on the work of other researchers. especially those which made messenger rna vaccines, hope against it possible to encapsulate in a lipid – a drop of fat – this extremely fragile RNA.
From COVID-19 to cancer – Messenger rna vaccines, hope against
The COVVI-19 pandemic gave a great accelerator to the development of this technology. Pfizer/Biontech and Moderna vaccines have proven its large -scale efficiency and safety.
We believe that this type of treatment could be put on the market available to patients within two. three or four years
Today, researchers hope to use this same technology as a treatment of certain cancers. Clinical trials are underway, especially against melanoma, pancreatic, lung cancer and brain tumors such as glioblastoma.
“We believe that this type of treatment could be put on the market available to patients within two. three or four years,” said Ugur Sahin, co -founder of Biontech.
Hope for cancers that are difficult to treat
Professor Olivier Michielin. head of the department of messenger rna vaccines, hope against oncology of Geneva University Hospitals, underlines the interest of this approach for resistant cancers like that of the pancreas: “These are tumors that resist treatments and mainly to immunotherapy. So. we did not necessarily have at the top to make vaccines on this kind of pathologies, but it is that a study has given an interesting results.”
Challenges to take up
Despite these hopes, challenges remain to be met. Personalization of vaccines for each patient poses logistical challenges. The high cost of these treatments also raises equitable access issues.
“In Switzerland, we have the desire and luxury of being able to give these innovative treatments to the global population. We will therefore really try to bring these vaccines to RNA. the day we have confirmation of their efficiency, to the greatest number”, reassures Olivier Michielin.
The future of this technology will also depend on investment in basic research. And one of the obstacles next messenger rna vaccines, hope against to that of the cost is that most clinical trials have been launched in the United States. that the current Minister of Health, Robert Kennedy Jr., has just blocked all funding for mesing VA vaccines.
TV reporting: Yelena Blessed, Tareq Daou, Ev Durá
Web adaptation: Gaëlle Bisson
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