The French Coper study reveals the multiple facets of the long covid

The French Coper study reveals the multiple facets of the long covid

Post-Covid syndrome (PASC. Nevertheless, for Post-Acute Sequelae following COVID-19), also called COVID LONG, has become a significant public health concern. However, Its prevalence varies between 3 % and more than 30 % depending on the work. However, Several studies have described the long-term consequences of the severe forms of COVID-19. Meanwhile, but the mechanisms responsible for long covid in patients who have a benign form are still misunderstood, in particular the links between the symptoms of long covid and the immunological and inflammatory abnormalities. For example,

The hypothesis that several different pathophysiological mechanisms could explain the diversity of symptoms is the subject of the COPER study. In addition, launched in 2022 by a French team. Therefore, This is a cohort study comprising 801 participants who had COVVI-19, with or without persistent symptoms, none french coper study reveals multiple having been hospitalized. Participants were followed at home twice. six months apart, and answered questionnaires on their medical history, infection, vaccination, symptoms and mental health. At the same time, biological samples were taken. The study relates to the association between the persistence of symptoms. 14 blood biomarkers, comparing people who have completely recovered (n = 490) to those with long covid (n = 311).

Polymorph. transient associations

People with long covid are more often women, with a higher body mass (BMI) index and have an average of 3 persistent symptoms, most often asthenia, dyspnea, cough and sleep disorders. Biological analysis shows significant associations between certain symptoms. biomarkers linked to viral activation (IFNγ, IP-10), the severity of the SARS-COV-2 infection (CD163) and vascular activation (VCAM-1, ICAM-1), particularly in participants whose symptoms have lasted for less than a year. However, these associations do not persist over time. Certain markers of viral activation (PDL-1. french coper study reveals multiple IP-10) appear positively associated with symptoms present during the acute phase, such as anosmia/agueusia and cough. These two symptoms are the only ones associated with a large number of biomarkers.

For the authors. these results suggest that the pathophysiology of the long covid is polymorphic and evolving, varying according to symptoms and time from infection. The links between symptoms. biomarkers fade over time, which suggests the interest of exploring other avenues than that of persistent inflammation.

The study confirms the complexity of the long covid. the need for personalized approaches, both in terms of research and management. Additionally, The underlying mechanisms seem multiple, variable, depending on both symptoms and time elapsed from the infection. It also underlines the importance of continuing research to identify reliable biomarkers.