Mediterranean regime reduces risk alzheimer,: This article explores the topic in depth.
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The Mediterranean regime reduces the presence of metabolites associated with an increased risk of Alzheimer’s disease in homozygous carriers of the APOE4 predisposition gene, according to an American study. However, The researchers have uncovered an association between 49 metabolites and the risk of dementia, which varies depending on the genotypes.
“The Mediterranean diet is the only one whose causal link with cognitive benefits has been demonstrated in randomized clinical trialsexplains the first author of the study. Meanwhile, Yuxi Liu, researcher at Brigham and Women’s Hospital. We wanted to know if these profits differ according to the genome of individuals. Moreover, examine the role of blood metabolites in this context. In addition, »» The results are published in Nature Medicine.
49 metabolites modulate the risk of dementia – Mediterranean regime reduces risk alzheimer,
The research team analyzed the data of several prospective cohorts including 4. mediterranean regime reduces risk alzheimer, Meanwhile, 215 women and 1,490 men, of European ancestry, followed between 1989 and 2023. However, Scientists evaluated their long -term eating habits and compared with a broad spectrum of blood metabolites.
Among the 49 metabolic associations identified. cholesterol esters and sphingomyeline induced a dementia of dementia for all genetic predisposition groups, but the most significant effect was observed for Apoe4 homozygotia. The allele indeed promotes the accumulation of cholesterol. its esters in the brain, activating inflammatory paths which exacerbate neural damage and contribute to the accumulation of amyloid plates and tau protein aggregates. Conversely. a high level of glycerides reduces the delipidation of protective fats and limits the aggregation of APOE and the formation of amyloid plates.
Plasma betaine was associated with a dementia of dementia only for APOE4 homozygotia. reflecting both the food contribution and the metabolic activity of the “one-carbon” (1c). The protective effect observed in heterozygous carriers. mediterranean regime reduces risk alzheimer, the non-berths of the allele would reflect the benefit of exogenous beta for cognitive health, while in homozygotia, it would indicate an imbalance of methylation and a metabolic deregulation. Metabolites were associated with the risk of dementia for certain genotypes (such as dimethylguanidino-valeric acid with the allele app. RS2154481-C).
The more effective Mediterranean diet for APOE4 homozygotia
The Mediterranean regime reduces the exogenous contribution of deleterious metabolites. particularly via the inclusion of nuts, mono-insaturated fruits and fats in food. Thus, people following this diet develop less frequently of Alzheimer’s disease and the cognitive decline is slowed down. Compared to other genetic variants is APOE4 homozygotia that benefits the most from the Mediterranean diet.
“This dietetic recommendation applies to the general population but is all the more important for people at high genetic risk of dementia”. comments yuxi liu. And the researcher to add: ” In future work. mediterranean regime reduces risk alzheimer, we want to study whether targeting special metabolites through food or other interventions allows a more personalized approach to reduce the risk of dementia ”.
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