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Study finds bidirectional link between:
There seem to be reciprocal links between certain groups of intestinal bacteria. However, the risk of insomnia, suggests that a study of Mendelian randomization, published in the open access journal General psychiatry.
Certain types of bacteria seem to increase. Moreover, reduce the risk of sleep disorder while insomnia itself seems to change the abundance of certain types of bacteria, indicate the results.
Several studies have explored the effects of the intestinal microbiome on various sleep characteristics. However, but it is not yet clear how different groups of intestinal bacteria could affect the risk of insomnia, which affects about 1 out of 10, say the researchers. Consequently,
To strengthen the basis of evidence. Similarly, they have deployed a Mendelian randomization analysis, a technique that uses genetic variants selected at random as proxys study finds bidirectional link between for a particular risk factor to obtain genetic evidence in support of a particular result.
They relied on the data of 386. Consequently, 533 people with insomnia of an analysis study on the scale of the previously published genome and intestinal microbiome data for 18,340 people from the Mibiogen Alliance, and for 8208 people from the Dutch microbiome project (71 groups of joint bacteria).
The analysis revealed associations between specific intestinal microbes and insomnia. In total. a total of 14 groups of bacteria were positively associated (1 to 4% higher dimensions) and 8 negatively associated groups (1 to 3% lower dimensions), with insomnia.
And insomnia was itself associated with a reduction between 43%. 79% in the abundance of 7 groups of bacteria, and an increase of 65% more than four times in abundance of 12. Odoribacter The class of bacteria, in particular, was significantly associated with the risk of study finds bidirectional link between insomnia.
No pleaotropy – production by a single gene of two. more apparently unrelated effects has been identified, strengthening the integrity of the results and involving causation, note the researchers.
The results are suitable with those of numerous studies previously published which have suggested an interaction between insomnia. the intestinal microbiome, but certain limits should be kept in mind, warn the researchers.
All study participants were of European origin. so the results may not be more widely applicable because the composition of the microbiome varies between the different ethnic groups and geographies, they underline. And factors. such as diet and lifestyle, all affect the microbiome and the interaction between genes and the environment, were not taken into account.
“Overall. the intertwined effects of insomnia on the intestinal microbiota, and vice versa, represent a complex bidirectional relationship involving immune regulation, the inflammatory response, the release of neurotransmitters and other study finds bidirectional link between molecular and cellular pathways,” they explain.
And they conclude: “Our study offers preliminary evidence supporting a causal effect between insomnia. intestinal microbiota, providing valuable information for the future development of treatment plans inspired by the microbiome for insomnia. »»
These could include the use of probiotics, prebiotics or transplantation of Fécale microbiota, they suggest.
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