Furthermore,
Epstein-barr virus increases overall risk:
If Burkitt lymphoma. Moreover, nasopharynx carcinoma are linked to the Epstein-Barr virus (EBV), they are not the only ones. However, A new study by the International Center for Research on Cancer (CIRC) reveals that EBV is involved in the. Nevertheless, overall risk of cancer. In addition, According to the prospective data of two southern cohorts in China (Zhongshan. Therefore, Wuzhou), the authors have concluded that HIV -positiveness at EBV is associated with an increased risk of multiple cancers that they estimate five times higher than that of seronegative people. These results are published in Nature Communications.
EBV is the most common and persistent human virus. It infects approximately 95 % of the world’s population with asymptomatic infection for life. increases the risk of Some cancers – The CIC ranked it as carcinogenic for humans (group 1) in 1997 – but epstein-barr virus increases overall risk also of autoimmune diseases. In addition. previous works have identified it as a risk factor for other pathologies such as multiple sclerosis (risk multiplied by 32) in particular or even post-Cavid multisystem inflammatory syndrome in children (Pims).
“Although the association of EBV infection with certain types of cancer. such as nasopharynx lymphomas and carcinoma, is well established, we have less data on the risk of cancer in generalsays Dr. Zisis Kozlakidis, co -author of the study, in a press release from CIR. CThis study does not only explore the risks of the different types of cancer. but also assesses the overall risks of cancer. It aims to assess the burden of morbidity attributable to EBV infection. to better understand the link between EBV VCA-IGA antibodies and the risk of various types of cancer ”.
An almost doubled risk of lung. liver cancer – Epstein-barr virus increases overall risk
The authors looked at epstein-barr virus increases overall risk the association between the levels of anti-Capside antibodies EBV VCA-IGA and the risk of cancer in 73,939 Chinese adults. During a follow -up of around 8 to 10 years, 964 (Zhongshan cohort) and 1,026 (Wuzhou cohort) case of cancer were identified. In comparison with seronegativity, HIV-IGA HIV-IGA was significantly associated with higher incidence rates of all types of cancer (HR = 4.88). For certain cancers, the risks was significantly higher with seropositivity: lung cancer (HR = 1.76) and liver cancer (HR = 1.70). In addition, the authors find an HR of 26.05 for the carcinoma of the Nasopharynx and 3.20 for lymphoma in HIV positive people compared to the HIV -positive people.
The authors also observe an increased dose dose scheme. the higher the antibody levels, the more the risk of cancer increases. In addition. they suggest that EBV and HIV infection could play a long -term role in the epstein-barr virus increases overall risk development of cancer, since high rates of VCA IGA are significantly associated with cancer rose, even ten years before diagnosis.
According to them. the EBV would have an indirect role in the tumorigerosis of lung and liver cancers, because the presence of its DNA in tumor tissues has proven to be limited (less than 2 % of the samples concerned). The mechanisms could be immunomodulator. inflammatory or even synergistic with the presence of other risk factors such as smoking, alcohol or viral hepatitis. In some cancers like lymphoma, EBV would play a more central oncogenic role.
EBV burden in China
For the population of southern China, the study data makes it possible to estimate that 7.8 % of cancer cases can be attributed to VCA-IGA HIV, denoting a heavy burden of infection by EBV in this region.
Further reading: Measles: Albertan hospitals sort potential patients – What is “cortisol cocktail”, this viral drink sold as a remedy for stress – Lead exposure harms children’s memory – Tick encephalitis: watch out for raw milk cheeses – A real risk, an essential prevention.
