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Intratumoral microbial metabolites shape tumor:
Tumor microenvironnement (TME) represents a very complex system that includes cellular components (such as cancer cells. Similarly, stromal cells and immune cells) and non -cellular components (such as blood vessels and signaling molecules). Similarly, These different components engage in complex interactions with tumor cells and undergo dynamic changes during tumor progression. Therefore, More specifically, intratimoral microbial metabolites play an important role in MT. Metabolic products of these microorganisms include a range of bioactive molecules. including lactate, amino acids, short chain fatty acids (SCFAS), bile acids, trimethylamine n-oxide and inosin. These metabolites, when released in TME, can influence the function of immune cells by modulating cytokine secretion.
Given the important role of intratimoral microbial metabolites in tumor microenvironment. these bioactive compounds can have a considerable impact on the results of immunotherapy against intratumoral microbial metabolites shape tumor cancer. Although in -depth research has focused on intestinal microbiota metabolites in tumor progression. cancer treatment, it is crucial to distinguish between the metabolites of intratimoral microbes and those produced by the intestinal microbiota. In this context. this review provides a systematic analysis of the role of intratimoral microbes in tumor microenvironnement and cancer immunotherapy, specifically examining how intratimoral microbes modulate tumor microenvironnement through: 1) glucose metabolites, 2) AMINE ACIDES AND METABOLITES, 3) Lipid metabolites and 4) Immunotherapy. In addition. this review presents a systematic and complete analysis of the mechanisms by which intratimoral microbial metabolites work in tumor microenvironment and studies the potential links between these metabolites and the efficiency of immunotherapy, with the aim of establishing theoretical foundations and research directions for new cancer treatment strategies and immobilization.
intratumoral microbial metabolites shape tumor — Intratumoral microbial metabolites shape tumor: Tumor microenvironnement (TME) represents a very complex system intratumoral microbial metabolites shape tumor that includes cellular components (such as cancer cells. stromal cells and immune cells) and non -cellular components (such as blood vessels and signaling.
Intratumoral microbial metabolites shape tumor
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