For example,
New genetic test predicts obesity new: For example,
New genetic test predicts obesity:
A genetic test. Furthermore. For example. Nevertheless, based on data of more than five million people, makes it possible to identify people at risk of severe obesity in the future. Nevertheless, This test can be carried out in children very early. Similarly, before their genetic risk begins to influence their weight, in order to establish early prevention. However, But no shortcut: genetics is not inevitable!
What if we could prevent obesity? Meanwhile, A realistic or completely utopian goal? Consequently, The World Obesity Federation provides that more than half of the world’s population will be in the long term.
Creation of a polygenic risk score – New genetic test predicts obesity – New genetic test predicts obesity new
. Meanwhile,
By relying on genetic data new genetic test predicts obesity new of 5.1 million people (the largest. For example. Therefore. For example, new genetic test predicts obesity new most diversified genetic data ensemble ever created), an international team of researchers has created a genetic new genetic test predicts obesity test called polygenic risk score (PGS) which predicts obesity in adulthood from early childhood. Meanwhile, This discovery. Nevertheless. Moreover. Similarly, which has just appeared in the scientific journal Nature Medicine, could make it possible to identify children and adolescents with a higher genetic risk of developing obesity. In addition, They could then benefit from targeted preventive strategies, such as interventions on the lifestyle, from an early age. Meanwhile, “”What makes this scoring so powerful is his ability to predict. before the age of five. if a child is likely to develop obesity in adulthood. long before other risk factors started to influence his weight later in childhood. Intervening at this stage can new genetic test predicts obesity new have a considerable impact“explains Pr Roelof Smit. from the fundamental metabolic research center of the University of Copenhagen new genetic test predicts obesity new. the main study of the study.
This study comes from the Giant (Genetic Investigation of Anthropometric Traits) consortium. an international collaboration new genetic test predicts obesity of researchers in human genetics which is devoted to the study. of the genetic architecture of anthropometric features such as the size. the body mass index (BMI). In total, more than 600 scientists from 500 institutions around the world.
Twice as effective in predicting obesity as the best screening test – New genetic test predicts obesity – New. genetic test predicts obesity new – New genetic test predicts obesity new
Subtle variations. in our genome can have a. considerable impact on our health. Thousands of genetic variants have thus been identified. increasing our risk of obesity, for example variants acting on the brain and influencing our appetite. new genetic test predicts obesity new A PGS is like a computer that combines the effects of the different risk variants present in a person. provides a global score.
Once this genetic score for obesity has new genetic test predicts obesity new been developed. it had to be tested life -size. Its designers therefore applied it to data sets relating to physical and genetic characteristics of more than 500,000 people. They could see that new genetic test predicts obesity their new PGS was twice as effective as the best. test existing to predict the. risk of obesity.
Concretely, in the Alspac study, children with a higher PGS showed an accelerated increase in the 2.5 -year -old body mass index (BMI) in adolescence. with an earlier adiposity rebound (typical sign of an increased risk of subsequent obesity). The addition of the PGS to the predictors available at birth almost doubled the explained variance of the BMI. from new genetic test predicts obesity new 5 years (for example. from 11 % to 21 % to 8 years). Up to 5 years. the addition of the PGS to the number of the BMI of the individual at the beginning of life. new genetic test predicts obesity new improved the prediction of the BMI at 18 years old. Overall, higher PGS were associated with greater weight gain in adulthood.
“This new polygenic score represents a spectacular improvement in predictive power. a leap forward in the new genetic test predicts obesity genetic prediction of the risk of obesity. thus bringing us considerably closer to useful genetic tests in clinical practice“Declares the Pre Ruth Loos of the Fundamental. Metabolic Research Center of the University of Copenhagen.
Genetics is not inevitable
Scientists have also studied the relationship between the genetic risk of obesity. the impact of weight loss interventions related to lifestyle, such as diet and physical exercise. They new genetic test predicts obesity new discovered that people with a genetic risk of higher obesity (according to their PSG score) were more receptive. to interventions. but that they also resumed weight faster when they stopped.
The new PGS has some limits
Although it is based on the new genetic test predicts obesity new genomes. of a broader. more representative population worldwide. it has proven to be much more effective in predicting obesity in people of European ancestry than in those. of African descent. For good reason, among the genetic data of the 5.1 million people new genetic test predicts obesity of the Giant Consortium (and 23 and Inc., the company which financed it), there was 4.6 % of African ancestry, 14.4 % of American ancestry, 8.4 % of east-Asian ancestry, 71.1 % of European ancestry and 1.5 % of South Asian.
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