Furthermore,
We know how stress linked:
Essential
- Oxidative stress -sensitive gene can push insulin -producing pancreatic cells to dysfunction. Consequently,
- When the activity of this gene called Redd2. Moreover, becomes too high, it leads to an increase in cell mortality within the pancreas, promoting type 2 diabetes. Nevertheless,
- This discovery opens the way to new treatments against type 2 diabetes. In addition,

. Similarly,
“Type 2 diabetes occurs when the β cells of the pancreas, which secrete insulin to regulate blood sugar, are altered due to prolonged stress caused by bad eating habits, a condition known as oxidative stress”explains Naoki Harada of the Metropolitan University of Osaka in a press release. But how can this stress play a role? The Japanese researcher now has the answer.
With his team, he identified a gene, we know how stress linked sensitive to oxidative stress, which leads pancreatic cells to work badly. The study was published in the journal Journal of Biological Chemistry in June 2025.

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Type 2 diabetes: a gene activated by the oxidative stress implicated – We know how stress linked
To better understand how type 2 diabetes occurs, scientists have looked into a stress response gene called Redd2. The latter is activated when the cells are under pressure and is supposed to help them manage stress. By studying it closely. the team discovered that Redd2’s activity increased, among other things, when the beta cells in the pancreas were subjected to high levels of glucose and fatty acids.
In addition, when REDD2 levels decrease rapidly, pancreatic cells manage to resume normal functioning without involvement on the organ. On the other hand, if the activity remains high or increased, the cell death rate at the pancreas also climbs. This promotes the appearance of dysfunctions when regulating we know how stress linked blood sugar.
Experiments carried out on mice that did not have a redd2 gene go in the direction of this observation. The rodents displayed better control of blood sugar than others when they were fed with a regime rich in fat. exposed to substances inducing diabetes. These animals also had more healthy beta cells and produced more insulin.
Redd2 gene and diabetes: to new treatments?

.
“We have discovered that the removal of Redd2’s expression protects the β cells from damage, even in the event of stress due to overeating, thus preventing the appearance of diabetes”Note Naoki Harada, principal author of the study. He ensures that this discovery could help to identify people at risk of type 2 diabetes more quickly.

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In addition, he adds that these “Results provide evidence that REDD2 is a potential therapeutic target for the treatment we know how stress linked of type 2 diabetes”.
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