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Discovery ally against exhaustion immune new: Therefore. However,
Discovery ally against exhaustion immune:
Researchers from the National Institute of Scientific Research (INRS). Therefore. For example. Meanwhile, McGill University have discovered a key factor capable of preserving the energy of CD8+immune cells, an advance opening the way to new strategies to strengthen immunity in the context of chronic infections or cancers.
Faced with chronic infections. Nevertheless, certain cancers, CD8+ T cells – real soldiers of the immune system – end up exhausting. However, They become less effective and respond less well to threats. However, This weakening is a major therapeutic issue, because it limits the ability of the body to resist chronic infections.
However. In addition. Moreover. Moreover, the team of Professor Simona Stäger at the National Institute of Scientific Research (INRS), in collaboration with her colleagues from INRS and McGill University, discovered a key player who could change the discovery ally against exhaustion immune new situation: the discovery ally against exhaustion immune new IRF-5 transcription factor. Additionally, Moreover, This key factor would be able to discovery ally against exhaustion immune preserve the energy. Consequently, vitality of these CD8+T cells, by acting directly on their metabolism.
These works. Similarly. Consequently. Therefore, recently published in the Embo Journal journal, illustrate the importance of basic research to better understand the workings of the immune system and develop innovative therapeutic approaches.
A key ally against the exhaustion of T cells
The exhaustion of T cells is caused by several factors. Moreover, including an imbalance in their internal functioning. Normally, these cells change their way of producing energy to react quickly to an infection. But when stimulation lasts too long. as in a chronic infection. their metabolism is exhausted. they produce less cytokines, chemical messengers essential to the immune response and their mitochondria, “energy power plants” of the cell, work discovery ally against exhaustion immune new less well, and they end up losing their effectiveness.
In this discovery ally against exhaustion immune new study. the research team used the LCMV Clone 13 virus. a chronic infection model. to explore the discovery ally against exhaustion immune role of the IRF-5 transcription factor in CD8+T cells. Although known in other cell types, its role in these cells has so far been unexplored.
“Our results show that IRF-5 acts as a real guardian of metabolism and the mitochondrial function of T cells. It helps T cells to keep their energy. their ability to fight. even in a situation of prolonged stress. ” explains the main author of the study, the professor at INRS Simona Stäger, an immunology expert in infectious diseases and infectiopole.
Scientists discovered that the absence of IRF-5 aggravates this exhaustion. CD8+ IRF-5 deficient cells have an impairment of their lipid metabolism. an increase in mitochondrial oxidative discovery ally against exhaustion immune new stress and a reduction in oxidative phosphorylation-all factors that affect their effectiveness.
A promising advance to better understand discovery ally against exhaustion immune new immunity
This discovery opens the way to. new strategies to strengthen immunity in. the context of chronic infections. cancers, where the exhaustion discovery ally against exhaustion immune of T cells is also observed. “I hope that our work will help better understand how to modulate cellular metabolism in order to support. strengthen the immune response during chronic infections or cancers. The IRF-5 transcription factor could play a key role in this approach. ”explains the first author of the study. Linh Thuy Mai. graduated from a doctorate in virology and immunology at INRS and currently postdoctoral researcher at the Albert Einstein College of Medicine in the United States.
(G.Q.)
Discovery ally against exhaustion immune new
Discovery ally against exhaustion immune new
Discovery ally against exhaustion immune
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discovery ally against exhaustion immune new
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