Fewer risk pregnancies due antiepileptic,: This article explores the topic in depth.
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Fewer risk pregnancies due antiepileptic. Moreover, :
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Published in the journal Neurology From the American Academy of Neurology, this work of the EPI-Phare Scientific Interest Group-which brings together the National Agency for the Safety of Medicines and Health Products and the CNAM-operate data from the National Health Data System (SNDS).
They show that out of 55. Nevertheless, 801 pregnancies exposed to at least one antiepileptic over the period 2013-2021, prenatal exhibition in valproate and its derivatives (Depakine And its generics), the most risky product, dropped from 84 % to 89 %, depending on the products.
This decrease results from several factors: a decline greater than 80 % of the number of pregnancies exposed. an increased appeal to the termination of pregnancy in the event of exposure, and a reduction in the number of women whose exposure during pregnancy has exceeded 30 days.
Taking valproate fewer risk pregnancies due antiepileptic, by pregnant women runs the child to be born a high risk of congenital malformations and neurodevelopmental disorders.
Little improvement for other treatments – Fewer risk pregnancies due antiepileptic,
On the other hand. the decline was less for the topiramate, sold under the brand Epitomax (Janssen) and carbamazepine (Tegretol) and their generics, which present “A risk of proven congenital malformations and a risk of proven neurodevelopmental disorders” For the first and ” potential “ For the second.
The pregnancies exposed to each of these drugs decreased 34 % and 40 % respectively, still over the period 2013-2021.
https://www.whatsupdoc-lemag.fr/article/faut-il-eviter-de-prescrire-de-la-depakine-aux-futurs-peres-les-medecins-et-la-communaute
For pregabalin. while it presents risks of malformation, and gabapentine, the exhibition in utero increased by 28 %, “With a trend in multiple prescriptions”.
At the same time. the use of antiepileptics with no risk identified during pregnancy, lamotrigine (Lamictal and generics) and levetiracetam, increased by 30 % between 2013 and 2021.
Precarious women ever more exposed
Source of concern: the study shows that “Exposure to fewer risk pregnancies due antiepileptic, proven. uncertain risk antiepileptics” Socially disadvantaged women have increased, even increased.
These inequalities. also observed in the Nordic countries and in the United Kingdom, known as the study, could be due to various factors, such as more frequent unplanned pregnancies and a deficit in prenatal care.
Consequently, the French health authorities must still strengthen the information of socially disadvantaged women, underlines the study.
In recent years. the ANSM has hardened its policy towards antiepileptics deemed at risk during pregnancy, as the involvement of several of these drugs in fetus disorders has been proven.
With AFP
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