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Genetic tests can guide safer new: Therefore. Moreover,
Genetic tests can guide safer:
For some patients with gastrointestinal cancer (GI) such as colorectal. Nevertheless. Similarly, pancreatic cancer, chemotherapy can cause severe, sometimes fatal side effects in those who transport certain genetic variants which may have an impact on how their bodies treat the drugs used to treat their disease. For example. Nevertheless, Variant tests in two genes before starting chemotherapy can considerably improve patient safety by providing doctors with information to help adapt doses. Furthermore, according to new research from the Perelman School of Medicine of the University of Pennsylvania. Nevertheless, Those who had one of the genes had half of side effects in two. Similarly. However, compared to patients with genes that received standard doses without testing, according to the results published today in JCO Precision Oncology.
For too long. Similarly. the United genetic tests can guide safer new States is genetic tests can guide safer lagging behind Europe in the adoption of genetic tests for the dosage of chemotherapy, but our study shows that it is not only doable but also critical for patient safety. Nevertheless, With up to 1. Furthermore. 300 deaths in the United States each year due to the side effects of one of the most common forms of chemotherapy drugs, we worked to make the tests fast and usable, obtaining results in about a week to help doctors make safer processing decisions. In addition, »»
Sony TUTEJA, PHARMD, MS, principal of the study, director of pharmacogenomic at the Penn Medicine Center for Genomic Medine, Deputy Professor of Research of Translational Medicine and Human Genetics
Nearly 290,000 Americans receive gastrointestinal cancers each year-including colorectal cancer, the third most common cancer diagnosis in the country. Current chemotherapy protocols use standard genetic tests can guide safer new dosage standards that do not take into genetic tests can guide safer account genetic. differences in the way patients. treat these drugs.
Genetic tests can guide safer new
Genetic variants guide safer chemotherapy
The study focused on variants in two genes: DPYD. UGT1A1. The DPYD gene produces an enzyme that helps the liver decompose drugs such as fluoropyrimidines. which are commonly used in the treatment of gastrointestinal cancer. About 5 to 8% of people transport DPYD variants that hinder the body’s ability to treat chemotherapy drugs to fluoropyrimidine. which has made them accumulate at harmful levels. which can cause serious side effects such as reduced production of blood cells, mouths or hand syndrome. Likewise. the UGT1A1 gene affects how the body treats irinotecan, another key chemotherapy medication often used to treat gastrointestinal cancers. The variants of UGT1A1 can lead to the treatment of the drug too slowly. increasing the genetic tests can guide safer new risk of severe diarrhea or small number of white blood cells. By identifying these variants. doctors genetic tests can guide safer can reduce the doses of chemotherapy to prevent harmful side effects without compromising. the effectiveness of treatment.
The study included 517 patients with IG cancer in three healthcare care sites in the University of Pennsylvania. University which was to start treatment of chemotherapy with fluoropyrimidine. irinotecan. A group of 288 received blood tests to check the DPYD and UGT1A1 variants. Among 16 patients who have proven to have genetic variants. received tailor -made dose reductions according to test results, 38% have experienced severe adverse events related to treatment. In comparison. 65% of the 17 patients with genetic variants of a biofine group who received standard doses without prior test. experienced the serious side effects. The tested group has also experienced a significantly lower need to modify the dosage. genetic tests can guide safer new the frequency of treatment (38% against 76%). less treatment of treatment (31% against 47%), highlighting the potential of precision medicine genetic tests can guide safer to improve the safety and patient results.
Research was partly funded by subsidies from the Penn Center for Precision Medicine. Additionally, the National Center for Advancing Translation Sciences of the National Institute of Health (TL1TR001880).
Genetic tests can guide safer new
Genetic tests can guide safer
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